Treatment outcomes of conventional or high-dose ranibizumab for vascularized pigment epithelial detachment based on lesion subtypes
Autor: | David Sarraf, Prema Abraham, Clement K. Chan |
---|---|
Rok vydání: | 2018 |
Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty genetic structures Post hoc Treatment outcome Visual Acuity Angiogenesis Inhibitors Retinal Pigment Epithelium Lesion Contrast Sensitivity 03 medical and health sciences 0302 clinical medicine Ophthalmology Ranibizumab Medicine Humans Prospective Studies Aged Aged 80 and over Analysis of Variance business.industry Retinal Detachment General Medicine Middle Aged eye diseases Choroidal Neovascularization Serous fluid Pigment epithelial detachment Intravitreal Injections 030221 ophthalmology & optometry Female sense organs medicine.symptom business 030217 neurology & neurosurgery Tomography Optical Coherence medicine.drug |
Zdroj: | European journal of ophthalmology. 28(6) |
ISSN: | 1724-6016 |
Popis: | Introduction: A post hoc study was conducted to compare visual and anatomic outcomes of vascularized serous pigment epithelial detachment (Group 1) with fibrovascular pigment epithelial detachment (Group 2) due to age-related macular degeneration treated with either 0.5 or 2.0 mg ranibizumab injections. Methods: A prospective, randomized trial was performed with the following regimens for 12 months: (1) 0.5 mg monthly, (2) 0.5 mg monthly for 4 months followed by pro re nata injections, (3) 2.0 mg monthly, and (4) 2.0 mg monthly for 4 months followed by pro re nata injections. Primary measure was best-corrected standardized vision. Secondary measures included central subfield, thickness surface area A2, greatest linear diameter, heights of pigment epithelial detachment and choroidal neovascularization (CNV), subretinal fluid, cystoid macular edema, and adverse events. Results: For 36 eyes (8 in Group 1 and 28 in Group 2), follow-up time was 12 months. There were no differences in baseline features between groups except for pigment epithelial detachment A2 (Group 2 > Group 1). Two-way analysis of variance showed comparable improvements in anatomic and vision outcomes. Three-way analysis of variance also showed similar responses for both lesion subtypes with high-dose treatment. There was a trend toward greater pigment epithelial detachment resolution in Group 1 eyes. There were no differences in retinochoroidal angiomatous proliferation (Type-3 CNV) and cataracts between groups, although greater percentages of eyes in Group 1 developed retinal pigment epithelial tears (25% vs 10.7%). Conclusion: There were no differences in vision and anatomic outcomes between lesion subtypes, and similarly, more rapid responses to high-dose than conventional-dose ranibizumab occurred for eyes with both lesion subtypes. More retinal pigment epithelial tears may develop in eyes with vascularized serous pigment epithelial detachment. |
Databáze: | OpenAIRE |
Externí odkaz: |