Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study
| Autor: | Elena Nazzari, S Ricci Bitti, Annamaria Colao, Manuela Albertelli, Rosario Pivonello, Rosa Pirchio, Ludovica F S Grasso, Andrea Dotto, Stefania Sciallero, Alberto Rebora, Mara Boschetti, Diego Ferone |
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| Přispěvatelé: | Albertelli, M, Nazzari, E, Dotto, A, Grasso, L F, Sciallero, S, Pirchio, R, Rebora, A, Boschetti, M, Pivonello, R, Ricci Bitti, S, Colao, A A L, Ferone, D |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Cross-sectional study Acromegaly Aged Aged 80 and over Colonic Polyps Colonoscopy Cross-Sectional Studies Female Humans Hypoglycemic Agents Incidence Metformin Middle Aged Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Context (language use) Overweight Gastroenterology 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine 80 and over Cross-Sectional Studie medicine.diagnostic_test Hypoglycemic Agent business.industry Incidence (epidemiology) General Medicine medicine.disease Colonic Polyp 030220 oncology & carcinogenesis Population study medicine.symptom business medicine.drug Human |
| Zdroj: | European journal of endocrinology. 184(3) |
| ISSN: | 1479-683X |
| Popis: | Context Colonic polyps occur in 30–40% of acromegalic patients, increasing the risk of colon carcinoma. Although debated, there is emerging evidence that metformin may play a protective role in diabetic and non-diabetic patients with colonic polyps and its use in chemoprevention is currently explored. Objective Evaluate the prevalence of colonic polyps in acromegalic patients treated or not with metformin and explore its possible protective role. Design Exploratory cross-sectional study in two tertiary Italian referral centres. Met hods: Out of 153 acromegalic patients, we selected 58 patients (36–82 years; f: 33) who had at least one colonoscopy performed within the first 2 years of diagnosis. Presence of colonic polyps/cancer and related risk factors, current metformin and acetylsalicylic acid intake, disease duration, therapies for acromegaly, hormonal and metabolic parameters were assessed. Results An overall prevalence of 36% polyps was found. Based on the presence of polyps, we identified two groups, comparable for age, BMI, disease duration, glucose, insulin, HOMA-IR, HbA1c, GH and IGF-I levels. Of the patients with polyps (including three adenocarcinomas) only 24% were treated with metformin vs 57% of patients without polyps. Multivariate analysis confirmed a significant negative association between colonic polyps and metformin intake (OR: 0.22, 95% CI: 0.06-0.77, P = 0.01), whereas no significant association was found between polyps and age (P = 0.10), overweight/obesity (P = 0.54), smoking (P = 0.15), acetylsalicylic acid intake (P = 0.99), disease duration (P = 0.96), somatostatin analogues treatment (P = 0.70). Conclusions These findings, though deriving from an exploratory study, could suggest a protective role of metformin on the development of colonic polyps in acromegaly, and need to be confirmed in an extended study population. |
| Databáze: | OpenAIRE |
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