Idiopathic recurrent acute pericarditis: a cross talk between autoimmunity and autoinflammation
| Autor: | Bruno Frediani, OM Lucherini, Antonio Vitale, Mauro Galeazzi, Isabella Muscari, Susanna Guerrini, Donato Rigante, Flora Magnotti, Luca Cantarini, Salvatore Napodano |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Autoimmune disease
business.industry Disease Recurrent acute medicine.disease_cause medicine.disease Idiopathic pericarditis Autoimmunity Pericarditis medicine.anatomical_structure Acute pericarditis Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA Immunology Medicine Pericardium business Autoinflammatory Disorders |
| Popis: | Idiopathic recurrent acute pericarditis is the most baffling drawback occurring in around 1/3 of patients who have suffered from acute pericarditis or complicating a host of systemic medical conditions. Various autoimmune diseases can involve the pericardium during the acute phase of the disease, even with no specific signs, and different cases of postviral pericarditis display an autoimmune background. In addition, some autoinflammatory disorders might display self-limited pericardial effusions, which are characterized by chronic recurrence. The clinical efficacy of corticosteroids should give support to the autoimmune origin of idiopathic recurrent acute pericarditis, but the dramatic response to interleukin-1 antagonists in patients with steroid-dependent idiopathic recurrent pericarditis should corroborate its autoinflammatory beginnings. The dividing line between the two medical settings is undefined and both autoimmune and autoinflammatory mechanisms should be advocated in the evaluation of this challenging pericardial disease. |
| Databáze: | OpenAIRE |
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