Causes of hypereosinophilia in 100 consecutive patients

Autor:	Janette van den Berghe, Helene Bruyere, Deonne Thaddeus V. Gauiran, Mollie N. Carruthers, Natasha Dehghan, Monika Hudoba, Nadia Medvedev, Julia Tan, Luke Y.C. Chen, Daniel Moller
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty Adolescent Context (language use) Hypereosinophilia Gastroenterology Immunophenotyping Diagnosis Differential Leukocyte Count Young Adult 03 medical and health sciences 0302 clinical medicine Bone Marrow Internal medicine Eosinophilia Hypereosinophilic Syndrome Eosinophilic medicine Humans Child reproductive and urinary physiology Aged Retrospective Studies Aged 80 and over business.industry Hypereosinophilic syndrome Disease Management Hematology General Medicine Middle Aged medicine.disease Organ Specificity 030220 oncology & carcinogenesis Female IgG4-related disease Disease Susceptibility biological phenomena cell phenomena and immunity medicine.symptom business Granulomatosis with polyangiitis Vasculitis Biomarkers 030215 immunology
Zdroj:	European Journal of Haematology. 105:292-301
ISSN:	1600-0609 0902-4441
Popis:	Background Hypereosinophilia (HE, persistent peripheral blood eosinophilia > 1.5 × 109 /L) and hypereosinophilic syndrome (HES, HE with end-organ damage) are classified as primary (due to a myeloid clone), secondary (due to a wide variety of reactive causes), or idiopathic. Diagnostic evaluation of eosinophilia is challenging, in part because secondary causes of HE/HES such as lymphocyte-variant HES (L-HES) and vasculitis are difficult to diagnose, and emerging causes such as immunoglobulin G4-related disease (IgG4-RD) have rarely been examined. Objective and methods We reviewed 100 consecutive patients with HE/HES who underwent extensive evaluation for primary and secondary eosinophilia at a single tertiary care center to determine causes of HE/HES in a modern context. Results Six patients had primary HE/HES, 80 had a discrete secondary cause identified, and 14 had idiopathic HE/HES. The most common causes of secondary eosinophilia were L-HES/HES of unknown significance (L-HESus) (20), IgG4-RD (9), and eosinophilic granulomatosis with polyangiitis (EGPA) (8). Conclusions In contrast to other large published series of HE/HES, most patients in this study were found to have a discrete secondary cause of eosinophilia and only 14 were deemed idiopathic. These findings highlight the importance of extensive evaluation for secondary causes of eosinophilia such as L-HES, IgG4-RD, and EGPA.
Databáze:	OpenAIRE
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