Effects of Acarbose on the Acceleration of Postprandial Hyperglycemia–Induced Pathological Changes Induced by Intermittent Hypoxia in Lean Mice
| Autor: | Chika Yamashita, Masatoshi Miyamura, Yasushi Kitaura, Toshitaka Yoshioka, Oliver Schnell, Tetsuya Hayashi, Tatsuhiko Mori, Chika Matsumoto, Nobukazu Ishizaka, Akira Ukimura, Yasuo Matsumura |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Blood sugar Biology medicine.disease_cause Muscle hypertrophy Mice Thinness Fibrosis Internal medicine Reaction Time medicine Animals Hypoxia Acarbose Pharmacology Myocardium lcsh:RM1-950 Intermittent hypoxia Hypoxia (medical) medicine.disease Mice Inbred C57BL lcsh:Therapeutics. Pharmacology Endocrinology Postprandial Hyperglycemia Molecular Medicine medicine.symptom Oxidative stress medicine.drug |
| Zdroj: | Journal of Pharmacological Sciences, Vol 114, Iss 1, Pp 32-40 (2010) |
| ISSN: | 1347-8648 1347-8613 |
| Popis: | Postprandial hyperglycemia (PPH) and intermittent hypoxia related to the sleep apnea syndrome are important predictors of cardiovascular disease. We investigated the effects of intermittent hypoxia on pathological changes in the left ventricular (LV) myocardium caused by PPH in lean mice and evaluated the influence of acarbose, an α-glucosidase inhibitor. Male C57BL/6J mice aged 8 weeks were exposed to intermittent hypoxia (8 h/day during the daytime) or kept under normoxia. PPH was induced by restriction of feeding to 1-h periods twice a day, with the restricted diet (RD) mice receiving either standard chow or chow containing 0.02% acarbose. Another group of mice were fed standard chow ad libitum (AL). Plasma glucose levels after food intake were significantly elevated in RD but not in AL mice, and glucose levels were suppressed by acarbose. Intermittent hypoxia exacerbated cardiomyocyte hypertrophy and interstitial fibrosis in the LV myocardium of RD mice. Superoxide production and expression of 4-hydroxy-2-nonenal in the LV myocardium with intermittent hypoxia were increased in RD mice, but not AL mice. In addition, expression of tumor necrosis factor α (TNF-α) mRNA was increased in hypoxic RD mice. Treatment with acarbose inhibited oxidative stress and TNF-α mRNA expression and preserved the histological architecture of the LV myocardium. Keywords:: α-glucosidase inhibitor, intermittent hypoxia, oxidative stress, postprandial hyperglycemia, sleep apnea |
| Databáze: | OpenAIRE |
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