Understanding Low Reliability of Memories for Neutral Information Encoded under Stress: Alterations in Memory-Related Activation in the Hippocampus and Midbrain
| Autor: | Shaozheng Qin, H.J.F. van Marle, Guillén Fernández, Erno J. Hermans |
|---|---|
| Přispěvatelé: | Psychiatry |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Time Factors Hydrocortisone Journal Club DCN MP - Plasticity and memory Effects of stress on memory Hippocampus Context (language use) Neuropsychological Tests Brain mapping 050105 experimental psychology Young Adult 03 medical and health sciences 0302 clinical medicine Heart Rate Mesencephalon 130 000 Cognitive Neurology & Memory Encoding (memory) Image Processing Computer-Assisted hippocampus and memory [130 001 Bridging the gap] Pupillary response medicine Humans 0501 psychology and cognitive sciences Saliva Pain Measurement Analysis of Variance Brain Mapping Memory Disorders medicine.diagnostic_test General Neuroscience 05 social sciences Pupil Articles Response bias Magnetic Resonance Imaging Oxygen 130 026 VENI Hermans ‘In a fit of fear’ Area Under Curve Case-Control Studies Psychology Functional magnetic resonance imaging Neuroscience Photic Stimulation Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Qin, S, Hermans, E J, van Marle, H J F & Fernandez, G 2012, ' Understanding Low Reliability of Memories for Neutral Information Encoded under Stress: Alterations in Memory-Related Activation in the Hippocampus and Midbrain ', Journal of Neuroscience, vol. 32, no. 12, pp. 4032-4041 . https://doi.org/10.1523/JNEUROSCI.3101-11.2012 The Journal of Neuroscience, 32, 12, pp. 4032-4041 Journal of Neuroscience, 32(12), 4032-4041. Society for Neuroscience Journal of Neuroscience The Journal of Neuroscience, 32, 4032-4041 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/JNEUROSCI.3101-11.2012 |
| Popis: | Contains fulltext : 110095.pdf (Publisher’s version ) (Open Access) Exposure to an acute stressor can lead to unreliable remembrance of intrinsically neutral information, as exemplified by low reliability of eyewitness memories, which stands in contrast with enhanced memory for the stressful incident itself. Stress-sensitive neuromodulators (e.g., catecholamines) are believed to cause this low reliability by altering neurocognitive processes underlying memory formation. Using event-related functional magnetic resonance imaging, we investigated neural activity during memory formation in 44 young, healthy human participants while incidentally encoding emotionally neutral, complex scenes embedded in either a stressful or neutral context. We recorded event-related pupil dilation responses as an indirect index of phasic noradrenergic activity. Autonomic, endocrine, and psychological measures were acquired to validate stress manipulation. Acute stress during encoding led to a more liberal response bias (more hits and false alarms) when testing memory for the scenes 24 h later. The strength of this bias correlated negatively with pupil dilation responses and positively with stress-induced heart rate increases at encoding. Acute stress, moreover, reduced subsequent memory effects (SMEs; items later remembered vs forgotten) in hippocampus and midbrain, and in pupil dilation responses. The diminished SMEs indicate reduced selectivity and specificity in mnemonic processing during memory formation. This is in line with a model in which stress-induced catecholaminergic hyperactivation alters phasic neuromodulatory signaling in memory-related circuits, resulting in generalized (gist-based) processing at the cost of specificity. Thus, one may speculate that loss of specificity may yield less discrete memory representations at time of encoding, thereby causing a more liberal response bias when probing these memories. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|