Determinant for multiple drug resistance possessing features of a mitochondrial episome in saccharomyces cerevisiae
| Autor: | V. L. Larionov, S. A. Neifakh, O. V. Nevzglyadova |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Mitochondrial DNA
Oligomycin Tetracycline Clinical Biochemistry Saccharomyces cerevisiae Extrachromosomal Inheritance Locus (genetics) Haploidy Cycloheximide chemistry.chemical_compound medicine Molecular Biology Alleles Crosses Genetic Genetics biology Drug Resistance Microbial Cell Biology General Medicine biology.organism_classification Mitochondria Multiple drug resistance Phenotype chemistry Mutation Oligomycins Ethidium bromide Plasmids medicine.drug |
| Zdroj: | Molecular and Cellular Biochemistry. 14:19-24 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/bf01734160 |
| Popis: | A mutation for multiple resistance to tetracycline, cycloheximide and oligomycin appears to be followed by reconstruction of the mitochondrial genome resulting in the formation of independent nucleotide sequences that determine different resistant phenotypes. Heterozygotes for the cross resistance factor lack locus T responsible for relation tetracycline which comes from the alpha-parent. The nuclear recessive gene-suppresor i induces deletion of the whole determinant for multiple resistance. The loss of mt-DNA on ethidium bromide treatment does not lead to the loss of this determinant which remains in the cells either in an active or in a passive state. |
| Databáze: | OpenAIRE |
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