X-linked codominant genes control all types of non-major histocompatibility complex-restricted cytotoxicity
| Autor: | Vanessa G. Lane, Ronald T. Acton, Carlo E. Grossi, Edgar F. Prasthofer, Daniela Zarcone, Arabella B. Tilden |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male X Chromosome Genetic Linkage Lymphocyte Immunology Biology Major histocompatibility complex Radiation Tolerance Natural killer cell Radiation sensitivity medicine Humans Immunology and Allergy Cytotoxic T cell Allele Killer Cells Lymphokine-Activated Cytotoxicity Genes Dominant Lymphokine-activated killer cell Antibody-Dependent Cell Cytotoxicity General Medicine Middle Aged Pedigree Killer Cells Natural medicine.anatomical_structure biology.protein Female |
| Zdroj: | Human Immunology. 30:208-214 |
| ISSN: | 0198-8859 |
| Popis: | In most individuals, natural killer (NK) activity is abolished after lymphocyte irradiation with 3,000 cGy, while lymphocytes from a minority of males retain 100% NK activity and lymphocytes from some females retain 50% NK activity after this dose. Radiation sensitivity of NK activity is controlled by X-linked codominant genes. The frequency of the allele that imparts resistance is 7%. We studied a unique family in which both parents have the resistant allele such that the father is completely resistant and the mother is partially resistant. The three offspring of this couple were one sensitive male, one partially resistant female, and one completely resistant female. The radiation sensitivity of nonspecific cytotoxic functions mediated by various types of effector cells from all five family members were evaluated in order to determine whether other cytotoxic functions were controlled by the same set of genes. The cytotoxic functions investigated were: NK and lymphokine-activated killing, anomalous killing and lectin-dependent cellular cytotoxicity, and antibody-dependent cell-mediated cytotoxicity. Our data indicate that the radiation sensitivity of all types of nonspecific cytotoxic cells is under the same genetic control. |
| Databáze: | OpenAIRE |
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