Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension

Autor: Susana Hoette, Luciana Tamie Kato-Morinaga, Mario Terra-Filho, Rogério Souza, Carlos Jardim, Willian Salibe-Filho, Ellen Pierre de Oliveira, Caio Julio Cesar dos Santos Fernandes
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Chronic Thromboembolic Pulmonary Hypertension
medicine.medical_specialty
Medicine (General)
Hypertension
Pulmonary
Perfusion Imaging
Ischemia
030204 cardiovascular system & hematology
Granulomatous Disease
Chronic
Lung Cavities
03 medical and health sciences
0302 clinical medicine
R5-920
medicine.artery
Thromboembolism
Parenchyma
medicine
Humans
030212 general & internal medicine
Lung
Retrospective Studies
Pulmonary Infarction
business.industry
Angiography
Anticoagulants
Retrospective cohort study
General Medicine
respiratory system
medicine.disease
Pulmonary hypertension
medicine.anatomical_structure
Treatment Outcome
Chronic Granulomatous Diseases
Chronic Disease
Etiology
Female
Original Article
Radiology
business
Bronchial artery
Pulmonary Embolism
Tomography
X-Ray Computed
Infection
Zdroj: Clinics, Vol 75 (2020)
Clinics, Volume: 75, Article number: e1373, Published: 10 JAN 2020
Clinics
Clinics; v. 75 (2020); e1373
Clinics; Vol. 75 (2020); e1373
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1980-5322
1807-5932
Popis: OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension (PH) that arises from obstruction of the pulmonary vessels by recanalized thromboembolic material. CTEPH has a wide range of radiologic presentations. Commonly, it presents as main pulmonary artery enlargement, peripheral vascular obstructions, bronchial artery dilations, and mosaic attenuation patterns. Nevertheless, other uncommon presentations have been described, such as lung cavities. These lesions may be solely related to chronic lung parenchyma ischemia but may also be a consequence of concomitant chronic infectious conditions. The objective of this study was to evaluate the different etiologies that cause lung cavities in CTEPH patients. METHODS: A retrospective data analysis of the medical records of CTEPH patients in a single reference PH center that contained or mentioned lung cavities was conducted between 2013 and 2016. RESULTS: Seven CTEPH patients with lung cavities were identified. The cavities had different sizes, locations, and wall thicknesses. In two patients, the cavities were attributed to pulmonary infarction; in 5 patients, an infectious etiology was identified. CONCLUSION: Despite the possibility of being solely associated with chronic lung parenchyma ischemia, most cases of lung cavities in CTEPH patients were associated with chronic granulomatous diseases, reinforcing the need for active investigation of infectious agents in this setting.
Databáze: OpenAIRE
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