Molecular basis of human hypertension: role of angiotensinogen
| Autor: | Florent Soubrier, Roger R. Williams, Steven C. Hunt, Richard P. Lifton, Jean Marc Lalouel, Yuri Kotelevtsev, Paul N. Hopkins, Christopher S. Williams, Pierre Corvol, Anne Charru, Xavier Jeunemaitre |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Paris Genetic Linkage Prohormone Molecular Sequence Data Angiotensinogen Disease Biology Essential hypertension General Biochemistry Genetics and Molecular Biology Genetic linkage Utah parasitic diseases Renin–angiotensin system Genotype medicine Humans Genetics Analysis of Variance Polymorphism Genetic Base Sequence Middle Aged medicine.disease Pedigree Plasma concentration Hypertension Angiotensinogen gene Female medicine.drug |
| Zdroj: | Cell. 71(1) |
| ISSN: | 0092-8674 |
| Popis: | Essential hypertension is a common human disease believed to result from the interplay of multiple genetic and environmental determinants. In genetic studies of two large panels of hypertensive sibships from widely separated geographical areas, we obtained evidence of genetic linkage between the angiotensinogen gene (AGT) and hypertension, demonstrated association of AGT molecular variants with the disease, and found significant differences in plasma concentrations of angiotensinogen among hypertensive subjects with different AGT genotypes. The corroboration and replication afforded by these results support the interpretation that molecular variants of AGT constitute inherited predispositions to essential hypertension in humans. |
| Databáze: | OpenAIRE |
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