Validity of ROX Index in Prediction of Risk of Intubation in Patients with COVID-19 Pneumonia
| Autor: | Taha Taha Abdelgawad, Heba Wagih Abdelwahab, Nesrine Saad Farrag, Lucy Abdelmabood Suliman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine 030506 rehabilitation medicine.medical_specialty Respiratory rate medicine.medical_treatment Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Respiratory Rate Oxygen therapy Internal medicine Severity of illness medicine ROX index COVID-19 intubation risk Humans Intubation Medical history business.industry Oxygen Inhalation Therapy Middle Aged medicine.disease Respiration Artificial Discontinuation Pneumonia Radiological weapon Female Blood Gas Analysis 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Advances in Respiratory Medicine; Volume 89; Issue 1; Pages: 1-7 |
| ISSN: | 2543-6031 |
| Popis: | Introduction: One important concern during the management of COVID-19 pneumonia patients with acute hypoxemic respiratory failure is early anticipation of the need for intubation. ROX is an index that can help in identification of patients with low and those with high risk of intubation. So, this study was planned to validate the diagnostic accuracy of the ROX index for prediction of COVID-19 pneumonia outcome (the need for intubation) and, in addition, to underline the significant association of the ROX index with clinical, radiological, demographic data. Material and methods: Sixty-nine RT-PCR positive COVID-19 patients were enrolled. The following data were collected: medical history, clinical classification of COVID-19 infection, the ROX index measured daily and the outcome assessment. Results: All patients with severe COVID-19 infection (100%) were intubated (50% of them on the 3rd day of admission), but only 38% of patients with moderate COVID-19 infection required intubation (all of them on the 3rd day of admission). The ROX index on the 1st day of admission was significantly associated with the presence of comorbidities, COVID-19 clinical classification, CT findings and intubation (p ≤ 0.001 for each of them). Regression analysis showed that sex and ROX.1 are the only significant independent predictors of intubation [AOR (95% CI): 16.9 (2.4– 117), 0.77 (0.69–0.86)], respectively. Cut-off point of the ROX index on the 1st day of admission was ≤ 25.26 (90.2% of sensitivity and 75% of specificity). Conclusions: ROX is a simple noninvasive promising tool for predicting discontinuation of high-flow oxygen therapy and could be used in the assessment of progress and the risk of intubation in COVID-19 patients with pneumonia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|