Short-term results of interventional therapy for infants (7–36 months old) with patent ductus arteriosus and moderate-to-severe pulmonary hypertension: a retrospective study

Autor: Dexing Zhou, Yilong Guo, Yue Shu, Xiaoqi Wang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Heart disease
Septal Occluder Device
Sedation
Hypertension
Pulmonary
lcsh:Surgery
Patent ductus arteriosus
030204 cardiovascular system & hematology
Pulmonary arterial hypertension
Severity of Illness Index
lcsh:RD78.3-87.3
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
030225 pediatrics
Ductus arteriosus
medicine
Humans
Ductus Arteriosus
Patent
Congenital heart disease
Retrospective Studies
Ejection fraction
business.industry
Infant
Retrospective cohort study
General Medicine
lcsh:RD1-811
medicine.disease
Pulmonary hypertension
Surgery
Cardiac surgery
medicine.anatomical_structure
Interventional therapy
Treatment Outcome
Cardiothoracic surgery
lcsh:Anesthesiology
Echocardiography
Child
Preschool
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Infants
Research Article
Zdroj: Journal of Cardiothoracic Surgery
Journal of Cardiothoracic Surgery, Vol 15, Iss 1, Pp 1-7 (2020)
ISSN: 1749-8090
Popis: Background Patent ductus arteriosus (PDA) is a common congenital heart disease. Interventional therapy is an important treatment for PDA. Nevertheless, few studies have investigated the safety and effectiveness of interventional therapy for infants (age, 0–36 months) with PDA and moderate-to-severe pulmonary hypertension. Therefore, this study aimed to analyze the short-term (6 months) results and interventional therapy experience for infants with PDA and moderate-to-severe pulmonary hypertension. Methods Clinical records, echocardiographic data, and angiocardiography data of 28 infants (age, 7–36 months) who underwent interventional therapy for PDA and moderate-to-severe pulmonary hypertension between December 2011 and January 2017 at our hospital were retrospectively analyzed. All infants were treated using an Amplatzer occluder with local and deep sedation anesthesia under radiographic guidance. Results Infants with PDA and moderate-to-severe pulmonary hypertension had poor growth. Trace residual shunts were found in two infants immediately after procedure; both had disappeared by 6 months after procedure. No significant interventional therapy-related complications occurred in the other cases. Pulmonary systolic pressure, left atrial dimension, and left ventricular end-diastolic dimension immediately after interventional therapy and 6 months later were lower than the preoperative levels (P P P = 0.505). Moreover, there were no significant differences in the left ventricular ejection fraction before, immediately after, and at 6 months after interventional therapy (P = 0.628). Conclusions For infants (age, 7–36 months) with PDA and moderate-to-severe pulmonary hypertension, interventional therapy can achieve excellent immediate and short-term (6 months) results with careful preoperative evaluations, strict operative procedures, and careful follow-up.
Databáze: OpenAIRE
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