Rhomboid-like proteins in Apicomplexa: phylogeny and nomenclature

Autor:	Timothy J. Dowse, Dominique Soldati
Jazyk:	angličtina
Rok vydání:	2005
Předmět:	Proteases Genes Protozoan Molecular Sequence Data Protozoan Proteins Zoology Biology Host-Parasite Interactions Apicomplexa Microneme 03 medical and health sciences Apicomplexa/classification/enzymology/genetics Phylogenetics parasitic diseases Animals Amino Acid Sequence Protozoan Proteins/chemistry/genetics/metabolism Peptide sequence Phylogeny 030304 developmental biology Genetics ddc:616 0303 health sciences Serine Endopeptidases/chemistry/genetics/metabolism 030306 microbiology Phylum Rhomboid Gene Expression Profiling Serine Endopeptidases Membrane Proteins biology.organism_classification Cell Adhesion Molecules/chemistry/genetics/metabolism Transmembrane domain Infectious Diseases Membrane Proteins/chemistry/genetics/metabolism Parasitology Cell Adhesion Molecules
Zdroj:	Trends in Parasitology, Vol. 21, No 6 (2005) pp. 254-258
ISSN:	1471-4922
Popis:	Rhomboids form a family of polytopic intramembrane serine proteases. In Toxoplasma gondii, an essential activity called microneme protein protease 1 (MPP1) cleaves secreted adhesive proteins within their transmembrane domains, at a site conserved in similar proteins of other Apicomplexa. Current evidence suggests that MPP1 is ubiquitous in the phylum and is encoded by a rhomboid gene. In this article, we present the current repertoire of rhomboid-like proteins in Apicomplexa using a nomenclature based on phylogenetic analyses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedfa282a62b44e7b6a2d830a3bfa863 https://archive-ouverte.unige.ch/unige:78029 Zobrazit plný text záznamu Full Text from ScienceDirect