Emergence of epidemic Neisseria meningitidis serogroup C in Niger, 2015: an analysis of national surveillance data

Autor: Goumbi Kadadé, Jibir Zanguina, Didier Mounkoro, Olivier Ronveaux, Sarah A. Meyer, Souleymane Sakande, Clement Lingani, Maman Zaneidou, Assimawe Pana, Jean Paul Moulia-Pelat, Fati Sidikou, Xin Wang, Ricardo Obama, Bassira Issaka, Stephanie Schwartz, Oubote Abodji, Odile Ouwe Missi Oukem-Boyer, Ryan T. Novak, Sani Ousmane, Flavien Ake, Innocent Nzeyimana, Ashley H. Tate, Ibrahim Alkassoum, Muhamed-Kheir Taha, Issaka Seidou
Přispěvatelé: Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES), Réseau International des Instituts Pasteur (RIIP), Direction de la Surveillance et de la Riposte aux Epidémies, Ministère de la Santé Publique [Niger], Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, World Health Organization [Niamey], World Health Organization Intercountry Support Team for West Africa, Agence de Médecine Préventive [Burkina Faso], Agence de Médecine Préventive [Togo], Infections Bactériennes Invasives, Institut Pasteur [Paris], Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Meningitis case-based surveillance in Niger is supported in part by the MenAfriNet consortium, a partnership between the US Centers for Disease Control and Prevention, WHO, and Agence de Médecine Preventive, through a grant from the Bill & Melinda Gates Foundation., Institut Pasteur [Paris] (IP)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: The Lancet Infectious Diseases
The Lancet Infectious Diseases, New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001-, 2016, ⟨10.1016/S1473-3099(16)30253-5⟩
The Lancet Infectious Diseases, 2016, ⟨10.1016/S1473-3099(16)30253-5⟩
ISSN: 1473-3099
1474-4457
Popis: Summary Background To combat Neisseria meningitidis serogroup A epidemics in the meningitis belt of sub-Saharan Africa, a meningococcal serogroup A conjugate vaccine (MACV) has been progressively rolled out since 2010. We report the first meningitis epidemic in Niger since the nationwide introduction of MACV. Methods We compiled and analysed nationwide case-based meningitis surveillance data in Niger. Cases were confirmed by culture or direct real-time PCR, or both, of cerebrospinal fluid specimens, and whole-genome sequencing was used to characterise isolates. Information on vaccination campaigns was collected by the Niger Ministry of Health and WHO. Findings From Jan 1 to June 30, 2015, 9367 suspected meningitis cases and 549 deaths were reported in Niger. Among 4301 cerebrospinal fluid specimens tested, 1603 (37·3%) were positive for a bacterial pathogen, including 1147 (71·5%) that were positive for N meningitidis serogroup C (NmC). Whole-genome sequencing of 77 NmC isolates revealed the strain to be ST-10217. Although vaccination campaigns were limited in scope because of a global vaccine shortage, 1·4 million people were vaccinated from March to June, 2015. Interpretation This epidemic represents the largest global NmC outbreak so far and shows the continued threat of N meningitidis in sub-Saharan Africa. The risk of further regional expansion of this novel clone highlights the need for continued strengthening of case-based surveillance. The availability of an affordable, multivalent conjugate vaccine may be important in future epidemic response. Funding MenAfriNet consortium, a partnership between the US Centers for Disease Control and Prevention, WHO, and Agence de Medecine Preventive, through a grant from the Bill & Melinda Gates Foundation.
Databáze: OpenAIRE
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