Effect of various drugs on spontaneous and surgically induced ventricular fibrillation in hypothermia
| Autor: | N. Margolis, H. E. D Amato, B. G. Covino |
|---|---|
| Rok vydání: | 1959 |
| Předmět: |
Quinidine
medicine.medical_specialty Hypothermia macromolecular substances Mephentermine Niacin Hypothermia Induced Internal medicine Humans Medicine Fibrillation business.industry Nicotinic Acids medicine.disease Cardiovascular Diseases Anesthesia Ventricular Fibrillation Ventricular fibrillation Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | American Heart Journal. 58:750-754 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/0002-8703(59)90234-0 |
| Popis: | The antifibrillary actions of Ambonestyl, quinidine, and mephentermine were studied on spontaneous ventricular fibrillation and on surgically induced ventricular fibrillation in the hypothermic dog. In addition, combinations of these agents were studied on spontaneous ventricular fibrillation in hypothermia. Mephentermine in a dose of 3 mg./Kg. significantly reduced the frequency of spontaneous ventricular fibrillation, whereas Ambonestyl and quinidine were not effective. When combined with either Ambonestyl or quinidine, mephentermine exerted the same antifibrillary effect. Surgically induced ventricular fibrillation in hypothermia was significantly reduced by quinidine (12 mg./Kg.) but not by Ambonestyl or mephentermine. The results indicate that the two situations (spontaneous and surgically induced fibrillation in hypothermia) are not entirely similar, that prevention of one does not imply prevention of the other, and that the factors predisposing the heart to fibrillation are different in the two conditions. |
| Databáze: | OpenAIRE |
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