Polymorphisms of the genes CTLA4, PTPN22, CD40, and PPARG and their roles in Graves' disease: susceptibility and clinical features

Autor:	Natassia Elena Bufalo, Angélica Gomes da Rocha, João H. Romaldini, Roberto B. Santos, Laura Sterian Ward, Larissa Teodoro
Rok vydání:	2020
Předmět:	Adult Male Peroxisome proliferator-activated receptor gamma medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism Graves' disease 030209 endocrinology & metabolism Trab Disease Gastroenterology Polymorphism Single Nucleotide PTPN22 Iodine Radioisotopes 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Gene Frequency Diabetes mellitus Internal medicine medicine Humans Clinical significance CTLA-4 Antigen Genetic Predisposition to Disease CD40 Antigens Aged business.industry Protein Tyrosine Phosphatase Non-Receptor Type 22 Middle Aged medicine.disease Graves Disease PPAR gamma 030220 oncology & carcinogenesis Case-Control Studies Female business Brazil
Zdroj:	Endocrine. 71(1)
ISSN:	1559-0100
Popis:	CTLA4, PTPN22, and CD40 are immune-regulatory genes strongly associated with GD, as well as PPARG, but their clinical significance in different populations is still uncertain. We genotyped 282 Brazilian GD patients (234 women and 48 men, 39.80 ± 11.69 years old), including 144 patients with GO, and 308 healthy control individuals (246 women and 62 men, 36.86 ± 12.95 years old). A multivariate analysis demonstrated that the inheritance of the GG genotype rs3087243 of CTLA4 (OR = 2.593; 95% CI = 1.630–4.123; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed90cd5ae79036be4f8055e411c2e97 https://pubmed.ncbi.nlm.nih.gov/32419081 Zobrazit plný text záznamu Full text from SpringerLink