Canine cognitive dysfunction patients have reduced total hippocampal volume compared with aging control dogs: A comparative magnetic resonance imaging study
Autor: | Mark Rishniw, Philippa J Johnson, Kelsey Robinson, Simon R. Platt, Curtis W. Dewey, Joseph Sackman, Marissa O'Donnell |
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Rok vydání: | 2021 |
Předmět: |
Male
Aging Pathology medicine.medical_specialty Cognitive Hippocampal formation Hippocampus Canine 03 medical and health sciences Dogs 0302 clinical medicine 030502 gerontology Dog medicine Animals Hippocampal Dementia Cognitive Dysfunction Dog Diseases Pathological Retrospective Studies Original Research General Veterinary medicine.diagnostic_test Volume business.industry Magnetic resonance imaging Cognition equipment and supplies medicine.disease Magnetic Resonance Imaging Hippocampal atrophy QL1-991 Brain size Hippocampal volume Female 0305 other medical science business Zoology 030217 neurology & neurosurgery |
Zdroj: | Open Veterinary Journal Open Veterinary Journal, Vol 10, Iss 4, Pp 438-442 (2020) |
ISSN: | 2218-6050 2226-4485 |
Popis: | Background: Hippocampal atrophy is a key pathologic and magnetic resonance imaging (MRI) feature of human Alzheimer’s disease (AD). Hippocampal atrophy has not been documented via MRI in canine cognitive dysfunction (CCD), which is considered as the dog model of human AD.Aim: The purpose of this retrospective comparative volumetric MRI study was to compare total hippocampal volumes between successfully aging (control) dogs and dogs diagnosed with CCD.Methods: Mimics® software was used to derive total hippocampal volumes and total brain volumes from the MRI studies of 42 aging dogs (≥ 9 years): 16 dogs diagnosed with CCD and 26 successfully aging controls. Hippocampal volumes were normalized to total brain volume and these values were compared between groups using Mann–Whitney U tests.Results: Total hippocampal volume normalized to total brain volume was significantly less for CCD patients compared with control dogs (p = 0.04).Conclusion: The results of this study suggest that – similar to human AD – hippocampal atrophy is a pathological feature of CCD. This finding has potential importance for both investigating disease mechanisms related to dementia as well as future hippocampal-targeted therapies. |
Databáze: | OpenAIRE |
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