Clinical Profile and Outcome of Patients with Cerebral Venous Thrombosis Secondary to Bacterial Infections

Autor:	Karthik Gunasekaran, C Vignesh Kumar, Manna Sera Jacob, Ramya Iyadurai, Ajoy Oommen, Angel Miraclin, Mohammad Sadiq, Maria Koshy, Ajay Kumar Mishra
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Pediatrics medicine.medical_specialty medicine.drug_class Antibiotics medicine.disease_cause lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine medicine 030212 general & internal medicine lcsh:Neurology. Diseases of the nervous system business.industry meningitis Parameningeal Retrospective cohort study cerebral venous thrombosis medicine.disease Venous thrombosis Staphylococcus aureus Etiology outcome Original Article Neurology (clinical) Bacterial infection Complication business Meningitis 030217 neurology & neurosurgery
Zdroj:	Annals of Indian Academy of Neurology Annals of Indian Academy of Neurology, Vol 23, Iss 4, Pp 477-481 (2020)
ISSN:	1998-3549 0972-2327
Popis:	Background: Cerebral venous thrombosis (CVT) secondary to infectious aetiology has become rare in the antibiotic era, but is still encountered in clinical practice occasionally. In this study, we describe the clinical profile, diagnosis, and management of patients with CVT secondary to an infectious aetiology. Methods: This retrospective study included all adult patients over 15 years (1 January 2002 to 1 January 2017). Adult patients with a diagnosis of infective CVT secondary to bacterial infections were included in the study. Results: Totally, 22 patients were identified with CVT complicating bacterial infections. The focus of infection in 12 (54.54%) patients was pyogenic meningitis, 9 (40.9%) patients had a parameningeal focus and one patient developed CVT secondary to bacterial sepsis from a remote focus. Fever was the most common symptom seen in 77.3% followed by headache and depressed sensorium in 72.7% and 63.6%, respectively. The most common organism in the meningitis group was Streptococcus species, and in the parameningeal group was Staphylococcus aureus. At presentation MRI identified CVT in all 7 patients as compared to CT brain with contrast in 2/3 (66.6%). Transverse sinus was the most commonly involved sinus in meningitis. All patients were treated with appropriate antibiotics and anticoagulation was used in 50% of the patients. The in hospital, mortaility was 9%. Conclusion: Septic CVT, though rare can be a complication of bacterial meningitis and facial infections. Clinical symptoms that suggest a co-existing CVT should be identified and diagnosed at the earliest. The mainstay of treatment is antibiotics; the role of anticoagulation is controversial.
Databáze:	OpenAIRE
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