Progressive strength training to prevent LYmphoedema in the first year after breast CAncer – the LYCA feasibility study
Autor: | Christoffer Johansen, Bo Zerahn, Niels Kroman, Susanne Oksbjerg Dalton, Ole Hyldegaard, Klaus Kaae Andersen, Charlotte Lanng, Gunn Ammitzbøll |
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Rok vydání: | 2017 |
Předmět: |
medicine.medical_specialty
Exacerbation Strength training Breast Cancer Lymphedema Breast Neoplasms Pilot Projects law.invention 03 medical and health sciences 0302 clinical medicine Breast cancer Primary outcome Randomized controlled trial law medicine Humans Radiology Nuclear Medicine and imaging Muscle Strength Prospective Studies 030212 general & internal medicine Prospective cohort study Aged business.industry Axillary Lymph Node Dissection Late effect Resistance Training Hematology General Medicine Middle Aged medicine.disease Oncology 030220 oncology & carcinogenesis Body Composition Physical therapy Feasibility Studies Female medicine.symptom business |
Zdroj: | Acta Oncologica. 56:360-366 |
ISSN: | 1651-226X 0284-186X |
Popis: | Lymphoedema is a common late effect after breast cancer (BC) that has no effective cure once chronic. Accumulating evidence supports progressive strength training (PRT) as a safe exercise modality in relation to the onset and exacerbation of lymphoedema. In the 'preventive intervention against LYmphoedema after breast CAncer' (LYCA) feasibility study we examined the feasibility of a program of PRT in the first year after BC to inform a planned randomised controlled trial (RCT).LYCA was a one-group prospective pilot trial inviting women operated with axillary lymph node dissection for unilateral primary BC. Participants exercised three times a week for 50 weeks (20 weeks supervised followed by 30 weeks home-based exercise). The program ensured slow individualised progression during the exercise program. The primary outcome was feasibility measured by eligibility and recruitment rates, as well as questionnaire-assessed satisfaction and adherence to exercise. Furthermore, we assessed arm interlimb volume difference by water displacement, muscle strength by dynamic and isometric muscle testing and range of movement in the shoulder by goniometry.In August 2015, eight of 11 eligible patients accepted participation. Two of them dropped out early due to other health issues. The remaining six participants had high exercise adherence through the supervised period, but only three maintained this through the home exercise period. Program satisfaction was high and no serious adverse events from testing or exercising were reported. One participant presented with lymphoedema at 50-week follow-up. Muscle strength markedly increased with supervised exercise, but was not fully maintained through the home exercise period. Range of shoulder movement was not negatively affected by the program.Recruitment, testing, and exercise in LYCA was safe and feasible. At the 50-week follow-up, there was one case of lymphoedema. The LYCA program will be further tested in a full-scale RCT. |
Databáze: | OpenAIRE |
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