Neuromodulation: A model for dopamine in salience encoding
| Autor: | Michael Bruchas, Jingyi Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Basal forebrain
Neurotransmitter Agents Dopamine Nucleus accumbens Biology General Biochemistry Genetics and Molecular Biology Nucleus Accumbens Article chemistry.chemical_compound Mice medicine.anatomical_structure chemistry Reward Salience (neuroscience) Neuromodulation medicine Animals General Agricultural and Biological Sciences Neurotransmitter Neuroscience Reinforcement Psychology medicine.drug |
| Zdroj: | Curr Biol |
| ISSN: | 1879-0445 |
| Popis: | A large body of work has aimed to define the precise information encoded by dopaminergic projections innervating the nucleus accumbens. Prevailing models are based on reward prediction error (RPE) theory where dopamine updates associations between rewards and predictive cues by encoding perceived errors between predictions and outcomes. However, RPE cannot describe multiple phenomena to which dopamine is inextricably linked, such as behavior driven by aversive and neutral stimuli. We combined a series of behavioral tasks with direct, subsecond dopamine monitoring in the nucleus accumbens (NAc) of mice, machine learning, computational modeling, and optogenetic manipulations to describe behavior and related dopamine release patterns across multiple contingencies reinforced by differentially valenced outcomes. We show that dopamine release only conforms to RPE predictions in a subset of learning scenarios but fits valence-independent perceived saliency encoding across conditions. Together, we provide an extended, comprehensive framework for accumbal dopamine release in behavioral control. |
| Databáze: | OpenAIRE |
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