Protective effect of rapamycin in models of retinal degeneration
| Autor: | Linchi Chen, Huanbing Tian, Shaobo Du, Ji Wang, Yongpeng Shi, Hanwen Cao, Shufan Qiao, Zhanyu Niu, Lan Gao, Li Wei, Jiande Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
cis-trans-Isomerases Retinal degeneration Rhodopsin Iodates Apoptosis Inflammation Retinal Pigment Epithelium Pharmacology Real-Time Polymerase Chain Reaction medicine.disease_cause Retina Mice Cellular and Molecular Neuroscience chemistry.chemical_compound Glial Fibrillary Acidic Protein In Situ Nick-End Labeling Animals Medicine Sodium iodate Sirolimus business.industry Retinal Degeneration Therapeutic effect Retinal Macular degeneration medicine.disease eye diseases Sensory Systems Disease Models Animal Oxidative Stress Ophthalmology chemistry medicine.symptom Reactive Oxygen Species business Immunosuppressive Agents Injections Intraperitoneal Oxidative stress |
| Zdroj: | Experimental Eye Research. 210:108700 |
| ISSN: | 0014-4835 |
| DOI: | 10.1016/j.exer.2021.108700 |
| Popis: | Age-related macular degeneration (AMD) is a complex retinal disease with no viable treatment strategy. The causative mechanistic pathway for this disease is not yet clear. Therefore, it is highly warranted to screen effective drugs to treat AMD. Rapamycin are known to inhibit inflammation and has been widely used in the clinic as an immunosuppressant. This study aimed to investigate the protective effect of rapamycin on the AMD retinal degeneration model. The AMD models were established by injection of 35 mg/kg sodium iodate (NaIO3) into the tail vein. Then the treated mice intraperitoneally received rapamycin (2 mg/kg) once a day. The histomorphological analysis showed that rapamycin could inhibit retinal structure damage and apoptosis. Experiments revealed that rapamycin significantly attenuated inflammatory response and oxidative stress. Our experimental results demonstrated that rapamycin has protected the retinal against degeneration induced by NaIO3. The therapeutic effect was more significant after 7 days of treatment. Therefore, our study potentially provides a powerful experimental support for the treatment of AMD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect