Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human
| Autor: | Ellen V. Rothenberg |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte 0301 basic medicine Cancer Research Receptors Antigen T-Cell alpha-beta Cell Cell Separation Thymus Gland Biology Article Transcriptome Mice 03 medical and health sciences Fetus 0302 clinical medicine Species Specificity Cell Movement Genetics medicine Animals Humans Cell Lineage Molecular Biology Cells Cultured Progenitor Precursor Cells T-Lymphoid Multipotent Stem Cells Tumor Suppressor Proteins Gene Expression Regulation Developmental Dendritic Cells Cell Biology Hematology Dendritic cell T lymphocyte In vitro Hematopoiesis Cell biology Repressor Proteins Haematopoiesis 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Single-Cell Analysis |
| Zdroj: | Exp Hematol |
| ISSN: | 0301-472X |
| Popis: | T-Cell development is a major branch of lymphoid development and a key output of hematopoiesis, especially in early life, but the molecular requirements for T-cell potential have remained obscure. Considerable advances have now been made toward solving this problem through single-cell transcriptome studies, interfaced with in vitro differentiation assays that monitor potential efficiently at the single-cell level. This review focuses on a series of recent reports studying mouse and human early T-cell precursors, both in the developing fetus and in stringently purified postnatal samples of intrathymic and prethymic T-lineage precursors. Cross-comparison of results reveals a robustly conserved core program in mouse and human, but with some informative and provocative variations between species and between ontogenic states. Repeated findings are the multipotent progenitor regulatory signature of thymus-seeding cells and the proximity of the T-cell program to dendritic cell programs, especially to plasmacytoid dendritic cells in humans. |
| Databáze: | OpenAIRE |
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