Adolescent cocaine induced persistent negative affect in female rats exposed to early-life stress

Autor:	M. Julia García-Fuster, Cristian Bis-Humbert
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Male media_common.quotation_subject Physiology Hippocampal formation Open field Rats Sprague-Dawley Cocaine-Related Disorders Neurochemical Cocaine Medicine Negative affect Animals FADD media_common Original Investigation Pharmacology Maternal deprivation biology business.industry Addiction Maternal Deprivation Abstinence Adolescence Rats biology.protein Rat Female business Stress Psychological Addiction vulnerability
Zdroj:	Psychopharmacology
ISSN:	1432-2072 0033-3158
Popis:	Rationale The combination of several risk factors (sex, a prior underlying psychiatric condition, or early drug initiation) could induce the emergence of negative affect during cocaine abstinence and increase the risk of developing addiction. However, most prior preclinical studies have been centered in male rodents, traditionally excluding females from these analyses. Objectives To ascertain the behavioral and neurochemical consequences of adolescent cocaine exposure when the combination of several risk factors is present (female, early-life stress). Methods Whole litters of Sprague–Dawley rats were exposed to maternal deprivation for 24 h on postnatal day (PND) 9. Cocaine was administered in adolescence (15 mg/kg/day, i.p., PND 33–39). Negative affect was assessed by several behavioral tests (forced swim, open field, novelty-suppressed feeding, sucrose preference). Hippocampal cell fate markers were evaluated by western blot (FADD, Bax, cytochrome c) or immunohistochemistry (Ki-67; cell proliferation). Results Maternal deprivation is a suitable model of psychiatric vulnerability in which to study the impact of adolescent cocaine in female rats. While adolescent cocaine did not alter affective-like behavior during adolescence, a pro-depressive–like state emerged during adulthood, exclusively in rats re-exposed to cocaine during abstinence. FADD regulation by cocaine in early-life stressed female rats might contribute to certain hippocampal neuroadaptations with some significance to the observed induced negative affect. Conclusions Adolescent cocaine induced persistent negative affect in female rats exposed to early-life stress, highlighting the risk of early drug initiation during adolescence for the emergence of negative reinforcement during abstinence likely driving cocaine addiction vulnerability, also in female rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed1006c2a9ebbcca2ded923c8c58ce1 http://europepmc.org/articles/PMC8629899 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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