Hippocampal Sequences During Exploration: Mechanisms and Functions
| Autor: | Céline Drieu, Michaël B. Zugaro |
|---|---|
| Přispěvatelé: | Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Computer science place cell [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Place cell Hippocampus Local field potential Review Hippocampal formation lcsh:RC321-571 memory 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Episodic memory lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ComputingMilieux_MISCELLANEOUS Adaptive behavior awake replay Recall phase precession network dynamics 030104 developmental biology Cellular Neuroscience Memory consolidation theta sequences Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Cellular Neuroscience Frontiers in Cellular Neuroscience, Frontiers, 2019, 13, ⟨10.3389/fncel.2019.00232⟩ Frontiers in Cellular Neuroscience, Vol 13 (2019) |
| ISSN: | 1662-5102 |
| DOI: | 10.3389/fncel.2019.00232⟩ |
| Popis: | Although the hippocampus plays a critical role in spatial and episodic memories, the mechanisms underlying memory formation, stabilization, and recall for adaptive behavior remain relatively unknown. During exploration, within single cycles of the ongoing theta rhythm that dominates hippocampal local field potentials, place cells form precisely ordered sequences of activity. These neural sequences result from the integration of both external inputs conveying sensory-motor information, and intrinsic network dynamics possibly related to memory processes. Their endogenous replay during subsequent sleep is critical for memory consolidation. The present review discusses possible mechanisms and functions of hippocampal theta sequences during exploration. We present several lines of evidence suggesting that these neural sequences play a key role in information processing and support the formation of initial memory traces, and discuss potential functional distinctions between neural sequences emerging during theta vs. awake sharp-wave ripples. |
| Databáze: | OpenAIRE |
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