Role of lipid-based excipients and their composition on the bioavailability of antiretroviral self-emulsifying formulations
| Autor: | Kamala K. Vasu, Manish Nivsarkar, Chamanlal Shishoo, Vineetkumar Patel, Arpan Chudasama |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Drug Materials science Nevirapine Anti-HIV Agents Chemistry Pharmaceutical media_common.quotation_subject Biological Availability Pharmaceutical Science Absorption (skin) Pharmacology Intestinal absorption Excipients Rats Sprague-Dawley Surface-Active Agents Drug Delivery Systems Suspensions Pulmonary surfactant medicine Animals Particle Size Solubility media_common Chromatography General Medicine Lipids Rats Bioavailability Intestinal Absorption Area Under Curve Drug delivery Emulsions medicine.drug |
| Zdroj: | Drug Delivery. 22:531-540 |
| ISSN: | 1521-0464 1071-7544 |
| DOI: | 10.3109/10717544.2014.891270 |
| Popis: | The objective of this study was to develop self-emulsifying drug delivery system (SEDDS) to improve solubility and enhance the oral absorption of the poorly water-soluble drug, nevirapine. This lipid-based formulation may help to target the drug to lymphoid organs where HIV-1 virus resides mainly. The influence of the oil, surfactant and co-surfactant types on the drug solubility and their ratios on forming efficient and stable SEDDS were investigated in detail. Two SEDDS (F1 and F2) were prepared and characterized by morphological observation, droplet size and zeta potential determination, cloud point measurement and in vitro diffusion study. The influence of droplet size on the absorption from formulations with varying concentration of oil and surfactant was also evaluated from two self-emulsifying formulations. Oral bioavailability of nevirapine SEDDS was checked by using rat model. Results of diffusion rate and oral bioavailability of nevirapine SEDDS were compared with marketed suspension. The absorption of nevirapine from F1 and F2 showed 1.92 and 1.98-fold increase (p |
| Databáze: | OpenAIRE |
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