Plasma C16-Cer levels are increased in patients with preterm labor
| Autor: | Janusz Kraczkowski, Agnieszka Blachnio-Zabielska, Piotr Laudanski, Rafał Kisielewski, Karol Charkiewicz, Marian Kacerovsky, Grzegorz Raba, Paweł Kuć, Piotr Zabielski, Ewa Koc-Zorawska, Violetta Dymicka-Piekarska, Adrian Chabowski, Bo Jacobsson |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Necrosis Physiology Gestational Age Inflammation Biology Ceramides Sensitivity and Specificity Biochemistry Pathogenesis 03 medical and health sciences Obstetric Labor Premature 0302 clinical medicine Pregnancy Tandem Mass Spectrometry medicine Humans Chromatography High Pressure Liquid Pharmacology 030219 obstetrics & reproductive medicine Case-control study Gestational age Cell Biology medicine.disease Sphingolipid 030104 developmental biology Apoptosis Case-Control Studies Immunology Female lipids (amino acids peptides and proteins) medicine.symptom Biomarkers Infant Premature |
| Zdroj: | Prostaglandins & Other Lipid Mediators. 123:40-45 |
| ISSN: | 1098-8823 |
| DOI: | 10.1016/j.prostaglandins.2016.04.005 |
| Popis: | The pathogenesis of preterm labor is fragmentarily explained. The most widely accepted theory points out to infection and inflammation as possible causes, which can be mediated by potentially different factors, including sphingolipid mediators. Sphingolipids are a class of lipids that have been shown as important mediators in various cell processes such as: proliferation, growth, apoptosis, stress response, necrosis and inflammation. The aim of the study was to assess plasma concentrations of selected sphingolipids in patients with preterm labor.We used ultra-high performance liquid chromatography with triple mass spectrometry (UHPLC-ESI-MS/MS) to assess plasma concentrations of the 11 sphingolipids in patients presenting with symptoms of preterm labor (n=61) and threatened preterm labor (n=40).We observed a statistically significant increase (p-value0.004) in plasma concentrations of C16-Cer in patients with preterm labor as compared to the control group. We also found C16-Cer to be the best predictor of preterm labor in the group of patients with symptoms occurring after 32 weeks of gestation.Our findings show a possible involvement of selected sphingolipids, especially C16-Cer, in the pathogenesis of preterm labor. Their role as predictors of preterm delivery needs to be validated in the future on larger group of patients. |
| Databáze: | OpenAIRE |
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