The effects of running exercise on oxidative capacity and PGC-1α mRNA levels in the soleus muscle of rats with metabolic syndrome
| Autor: | Hidemi Fujino, Hiroyo Kondo, Kinsuke Tsuda, Isao Takeda, Fumiko Nagatomo, Akihiko Ishihara, Motoki Kouzaki, Ning Gu |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Cell physiology
Blood Glucose Male medicine.medical_specialty Physiology Muscle Fibers Skeletal Physical Exertion Rats Inbred WKY Triglyceride Rats Mutant Strains Running chemistry.chemical_compound Internal medicine medicine Animals RNA Messenger Obesity Receptor Muscle Skeletal DNA Primers Soleus muscle Hypertriglyceridemia Metabolic Syndrome biology Adiponectin Base Sequence Succinate dehydrogenase Succinate dehydrogenase activity RNA-Binding Proteins medicine.disease Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Muscle fiber type Rats Succinate Dehydrogenase Disease Models Animal Endocrinology chemistry biology.protein Metabolic syndrome Oxidation-Reduction Transcription Factors |
| Zdroj: | The journal of physiological sciences : JPS. 62(2):105-114 |
| ISSN: | 1880-6562 |
| Popis: | Skeletal muscles in animals with metabolic syndrome exhibit reduced oxidative capacity. We investigated the effects of running exercise on fiber characteristics, oxidative capacity, and mRNA levels in the soleus muscles of rats with metabolic syndrome [SHR/NDmcr-cp (cp/cp); CP]. We divided 5-week-old CP rats into non-exercise (CP) and exercise (CP-Ex) groups. Wistar-Kyoto rats (WKY) were used as the control group. CP-Ex rats were permitted voluntary exercise on running wheels for 10 weeks. Triglyceride levels were higher and adiponectin levels lower in the CP and CP-Ex groups than in the WKY group. However, triglyceride levels were lower and adiponectin levels higher in the CP-Ex group than in the CP group. The soleus muscles in CP-Ex rats contained only high-oxidative type I fibers, whereas those in WKY and CP rats contained type I, IIA, and IIC fibers. Muscle succinate dehydrogenase (SDH) activity was higher in the CP-Ex group than in the CP group; there was no difference in SDH activity between the WKY and CP-Ex groups. Muscle proliferator-activated receptor γ coactivator-1α (PGC-1α) mRNA levels were higher in the CP-Ex group than in the CP group; there was no difference in PGC-1α mRNA levels between the WKY and CP-Ex groups. In CP-Ex rats, longer running distance was associated with increased muscle SDH activity and PGC-1α mRNA levels. We concluded that running exercise restored decreased muscle oxidative capacity and PGC-1α mRNA levels and improved hypertriglyceridemia in rats with metabolic syndrome. |
| Databáze: | OpenAIRE |
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