Absence of a Pharmacokinetic Interaction Between Intravenous Theophylline and Orally Administered Levofloxacin
| Autor: | Barry Hafkin, Jaya Natarajan, R. Rex Williams, Cynthia L. Fowler, Lee G. Gisclon, Christopher R. Curtin |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Ofloxacin medicine.drug_class Cmax Levofloxacin Pharmacology Anti-Infective Agents Double-Blind Method Theophylline Pharmacokinetics Oral administration Bronchodilator medicine Humans Pharmacology (medical) Antibacterial agent Cross-Over Studies business.industry Crossover study Bronchodilator Agents Anesthesia Injections Intravenous business Half-Life medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 37:744-750 |
| ISSN: | 0091-2700 |
| DOI: | 10.1002/j.1552-4604.1997.tb04362.x |
| Popis: | A randomized, placebo-controlled, two-way crossover study in 16 healthy men was performed to determine the effect of orally administered levofloxacin at steady-state conditions, given at 500 mg every 12 hours, on the pharmacokinetics of theophylline given as a single 4.5-mg/kg intravenous infusion. Participants were assigned randomly to receive theophylline with levofloxacin in one study period and theophylline with placebo in the other period. Fourteen individuals completed the study. Mean (+/-SD) values for theophylline pharmacokinetic parameters for the levofloxacin and placebo treatments, respectively, were peak plasma concentrations (Cmax) of 11.4 (1.8) micrograms/mL and 10.7 (1.3) micrograms/mL; areas under the concentration time curve from time 0 extrapolated to infinity (AUCzero-infinity) of 124 (32) micrograms.hr/mL and 126 (30) micrograms.hr/mL; volumes of distribution at steady state (Vdss) 31.7 (3.5) L and 32.0 (3.9) L; clearances (Cl) of 48.6 (11.6) mL/min and 47.4 (10.3) mL/min; and half-lives (t1/2) of 8.1 (1.9) hours and 8.2 (1.8) hours. There were no statistically significant differences between treatments for any of these parameters. There was no pharmacokinetic interaction between levofloxacin administered orally at steady-state conditions and intravenously administered theophylline. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text