Predicting systemic spread in early colorectal cancer: Can we do better?
| Autor: | Scarlet Brockmoeller, Nicholas P. West |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Local excision Lymphovascular invasion Colorectal cancer medicine.medical_treatment Novel histopathology parameters Lymph node metastasis 0302 clinical medicine Risk Factors Mass Screening Intestinal Mucosa Colectomy Early Detection of Cancer Observer Variation Proctectomy Gastroenterology Minireviews General Medicine Prognosis 3. Good health Lymphatic Metastasis 030220 oncology & carcinogenesis Practice Guidelines as Topic Local resection Tumour budding 030211 gastroenterology & hepatology Colorectal Neoplasms Bowel cancer screening medicine.medical_specialty Early colorectal cancer Morphological risk factors Adenocarcinoma Risk Assessment 03 medical and health sciences Internal medicine medicine Tumour grading Humans Digital pathology Neoplasm Invasiveness Risk stratification models Neoplasm Staging business.industry Major resection medicine.disease Polypectomy Conventional histopathology parameters Lymph Nodes Neoplasm Grading business |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v25.i23.2887 |
| Popis: | Through the implementation of national bowel cancer screening programmes we have seen a three-fold increase in early pT1 colorectal cancers, but how these lesions should be managed is currently unclear. Local excision can be an attractive option, especially for fragile patients with multiple comorbidities, but it is only safe from an oncological point of view in the absence of lymph node metastasis. Patient risk stratification through careful analysis of histopathological features in local excision or polypectomy specimens should be performed according to national guidelines to avoid under- or over-treatment. Currently national guidelines vary in their recommendations as to which factors should be routinely reported and there is no established multivariate risk stratification model to determine which patients should be offered major resectional surgery. Conventional histopathological parameters such as tumour grading or lymphovascular invasion have been shown to be predictive of lymph node metastasis in a number of studies but the inter- and intra-observer variation in reporting is high. Newer parameters including tumour budding and poorly differentiated clusters have been shown to have great potential, but again some improvement in the inter-observer variation is required. With the implementation of digital pathology into clinical practice, quantitative parameters like depth/area of submucosal invasion and proportion of stroma can be routinely assessed. In this review we present the various histopathological risk factors for predicting systemic spread in pT1 colorectal cancer and introduce potential novel quantitative variables and multivariable risk models that could be used to better define the optimal treatment of this increasingly common disease. |
| Databáze: | OpenAIRE |
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