SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer
| Autor: | Hailong Jiang, Jie Wang, Wenjun Chang, Chuan-Xiang Zhou, An Li, Fuao Cao, Yan Huang, Yamin Pan, Lei Qiu, Jianzhong Li, Hao Shen, Yiming Lu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology STAT3 Transcription Factor medicine.medical_specialty Colorectal cancer Active Transport Cell Nucleus lcsh:Medicine Protein Tyrosine Phosphatase Non-Receptor Type 11 Protein tyrosine phosphatase Article 03 medical and health sciences 0302 clinical medicine Breast cancer Cell Movement Internal medicine Cell Line Tumor medicine Humans Phosphorylation lcsh:Science Cell Proliferation Cell Nucleus Multidisciplinary business.industry Proportional hazards model Cell growth lcsh:R medicine.disease Prognosis PTPN11 Cell nucleus 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cohort Disease Progression lcsh:Q business Colorectal Neoplasms |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Tyrosine phosphatase SHP2, encoded by PTPN11, has been implicated in many physiologic and pathologic processes in neoplastic progression. However, controversies are emerging from many studies, indicating SHP2 has a dual role in different types of tumors. We aimed to explore the role of SHP2 in progression and prognosis of colorectal cancer (CRC). SHP2 inhibited CRC cell proliferation and migration, and the phosphorylation of STAT3 was negatively regulated by SHP2 in CRC. SHP2 and nuclear STAT3 were examined in 270 CRC tissues. SHP2 was significantly correlated with nuclear STAT3 (Spearman’s rho = −0.408, P ≤ 0.001). Based on Cox regression analysis, patients with high levels of SHP2 and low levels of nuclear STAT3 had longer disease-specific survival (DSS) (HR, 0.362; 95% CI, 0.165–0.794) and disease-free survival (DFS) (HR, 0.447; 95% CI, 0.227–0.877). Further, low levels of SHP2 and high levels of nuclear STAT3 were independently associated with adverse outcomes in the whole cohort (DFS; HR, 2.353; 95% CI, 1.199–4.619). These results suggest that combination of SHP2 and nuclear STAT3 is a strong prognostic predictor in CRC. |
| Databáze: | OpenAIRE |
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