Is the Skin Absorption of Hydrocortisone Modified by the Variability in Dosing Topical Products?

Autor:	Elizabeth Jenkins, Daniel Paterson, Jacqueline Hallier, Maria Delgado-Charro, Sarah F. Cordery
Rok vydání:	2018
Předmět:	tape-stripping lcsh:RS1-441 Pharmaceutical Science Absorption (skin) Pharmacology 030226 pharmacology & pharmacy Article patient education lcsh:Pharmacy and materia medica 030207 dermatology & venereal diseases 03 medical and health sciences fingertip unit 0302 clinical medicine In vivo dosing variability hydrocortisone skin absorption topical corticosteroids medicine Stratum corneum Dosing Hydrocortisone FINGERTIP UNIT business.industry In vitro permeation medicine.anatomical_structure business medicine.drug
Zdroj:	Pharmaceutics, Vol 10, Iss 1, p 9 (2018) Paterson, D, Hallier, J, Jenkins, E, Cordery, S & Delgado-Charro, M 2018, ' Is the Skin Absorption of Hydrocortisone Modified by the Variability in Dosing Topical Products? ' Pharmaceutics, vol. 10, no. 9 . https://doi.org/10.3390/pharmaceutics10010009 Pharmaceutics Pharmaceutics; Volume 10; Issue 1; Pages: 9
ISSN:	1999-4923
Popis:	Fingertip units have been proposed as a tool to standardize topical therapy with semisolid formulations. However, no studies to date have characterized the variability in dosing by patients using this concept and whether this variability ultimately affects the topical absorption of drugs. This work aimed to answer these two questions. A first study determined the dose measured, the area of spread and the area-normalized dose for a 1% hydrocortisone cream and ointment applied by members of the public using this dosing approach before and after brief counselling. Then, in vivo tape-stripping and in vitro permeation studies investigated whether the variability in the area-normalized dose altered the skin absorption of hydrocortisone. Participants applied greater doses and spread them over larger areas after a short counselling intervention leading to smaller area-normalized doses. In vivo hydrocortisone uptake by the stratum corneum was significantly greater for the higher normalized dose and the differences were further supported by the in vitro permeation studies. However, these differences were relatively small and not proportional to the increase in normalized dose. This work shows that, following brief advice, patients and carers can apply consistent and sufficient doses of corticosteroids whilst minimizing risks and variability in hydrocortisone absorption.
Databáze:	OpenAIRE
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