Acute effect of β amyloid on synchronized spontaneous Ca2+ oscillations in cultured hippocampal networks
| Autor: | Yan-fang Rui, Ruxin Li, Shaoqing Zhu, Zuoping Xie, Xinzhu Yu, Zhong-hua Sheng, Yifu Liu |
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| Rok vydání: | 2006 |
| Předmět: |
Cytoplasm
medicine.medical_specialty Time Factors Acute effect Hippocampal formation Hippocampus β amyloid Internal medicine medicine Animals Ca2 oscillations Calcium Signaling Cells Cultured Neurons Amyloid beta-Peptides Chemistry Cell Biology General Medicine Differential effects Peptide Fragments Rats medicine.anatomical_structure Endocrinology Neuron Ca2 imaging |
| Zdroj: | Cell Biology International. 30:733-740 |
| ISSN: | 1065-6995 |
| Popis: | The effects of beta amyloid (Abeta) on cytoplasmic Ca(2+) ([Ca(2+)](c)) have been studied extensively, but the current literature on this aspect is confusing. We reported that 20 microM Abeta(25-35) significantly inhibited the synchronized spontaneous cytoplasmic Ca(2+) transients immediately after application, whereas it had little effect on the baseline [Ca(2+)](c) concentration in neurons. Abeta(1-42) had a similar effect on the Ca(2+) transients as Abeta(25-35), while it increased baseline [Ca(2+)](c) concentration gradually. However, Abeta(1-40) had little effect on either Ca(2+) transients or baseline [Ca(2+)](c). Such differential effects of Abeta on Ca(2+) signals might explain, at least partially, the confusing observations from the previous studies and provide important therapeutic implications for preventing or reversing early neuron damage in Alzheimer's disease. |
| Databáze: | OpenAIRE |
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