Lactic acid, neuron-specific enolase, and blood-brain barrier index after a severe traumatic brain injury: a prospective study
| Autor: | Guizhong Yan, Yi Chen, Cheng Jiang, Ruo-bing Bai, Haijun Ren, Wei-xin Lu, Ze-Ning Wang, Gang Wang |
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| Rok vydání: | 2020 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty Traumatic brain injury Enolase Blood–brain barrier 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cerebrospinal fluid medicine Clinical significance Intracranial pressure business.industry Glasgow Coma Scale General Medicine medicine.disease Lactic acid medicine.anatomical_structure nervous system chemistry 030220 oncology & carcinogenesis Surgery Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | British journal of neurosurgery. |
| ISSN: | 1360-046X |
| Popis: | To explore the clinical significance of dynamic monitoring of cerebrospinal fluid (CSF) and serum Lactic acid（Lac), neuron-specific enolase (NSE), and the blood-brain barrier (BBB) index in evaluating the condition and prognosis after a severe traumatic brain injury (TBI).A total of 52 severe TBI patients admitted to the Department of Neurosurgery within 24 hours after injury were dynamically monitored. CSF and serum samples were collected on the 1st, 3rd, and 7th day after a severe TBI to monitor the changes in Lac, NSE, and the BBB index. Intracranial pressure (ICP), Glasgow coma scale (GCS), and 6-month Glasgow outcome scale-extended (GOS-E) were tested. According to the results of GOS-E, the patients were divided into two groups (i.e. the poor prognosis group and good prognosis group). Statistical analysis was conducted to investigate the clinical significance of dynamic monitoring of CSF and serum Lac, NSE, and BBB index after a severe TBI.After a severe TBI, the levels of Lac, NSE, and BBB in CSF and serum were significantly higher than those in the normal range. Lac, NSE, and the BBB index did not correlate with ICP (except serum Lac) but had correlations with GCS and post-injury 6 months post-injury (except serum Lac). Moreover, the correlations between Lac, NSE, and BBB index were statistically significant (After a severe TBI, dynamic monitoring of CSF and serum Lac, NSE, and BBB index has the potential to assess the condition, predict the prognosis, and have clinical significance. |
| Databáze: | OpenAIRE |
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