High-dose-rate brachytherapy in early oral cancer with close or positive margins
| Autor: | Linda Kašaová, Helena Doležalová, Igor Sirák, Luboš Tuček, Jiří Petera, Jan Laco |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty medicine.medical_treatment Brachytherapy Urology Salvage therapy Kaplan-Meier Estimate Disease-Free Survival Biomarkers Tumor Humans Medicine Neoplasm Invasiveness Radiology Nuclear Medicine and imaging Stage (cooking) Aged Retrospective Studies Salvage Therapy Mouth neoplasm business.industry Cancer Neck dissection Middle Aged medicine.disease High-Dose Rate Brachytherapy Oncology Multivariate Analysis Resection margin Female Mouth Neoplasms business Nuclear medicine |
| Zdroj: | Brachytherapy. 14:77-83 |
| ISSN: | 1538-4721 |
| Popis: | PURPOSE: Retrospective evaluation of high-dose-rate brachytherapy (HDR BT) in early oral can- cer and factors influencing tumor control. METHODS AND MATERIALS: A total of 30 patients with T1eT3N0 tongue and floor of mouth cancer were treated with tumor excisionelective neck dissection and HDR BT 18 � 3 Gy b.i.d. The KaplaneMeier model was used for survival analyses, and the log-rank test and Cox regression analyses were used to evaluate the influence of T-stage, histologic grade, resection margin, depth of invasion, and vascular endothelial growth factor (VEGF) intensity on local control (LC), nodal control (NC), disease-free survival (DFS), and overall survival (OS). Median followup was 40 months (6e145). RESULTS: Actuarial 3-year LC, NC, DFS, DFS after salvage treatment, and OS were 85.4%, 69.2%, 65.4%, 75.6%, and 73.0%, respectively. The log-rank test and univariate Cox regression anal- ysis revealed the following correlations, namely tumor grade correlated with LC, DFS, and OS; T- stage with NC and DFS; depth of invasion and VEGF intensity with NC, DFS, and OS. Associations detected on the multivariate analysis were as follows: tumor grade with LC, depth of invasion with NC, depth of invasion and tumor grade with DFS, and VEGF intensity with DFS after salvage treat- ment. Only one case of osteoradionecrosis and two cases of soft tissue necrosis occurred. CONSLUSION: The HDR BT 18 � 3 Gy b.i.d. is a safe treatment of early oral cancer with a good LC. The T-stage, tumor grade, depth of invasion, and intensity of VEGF were significant predictors of locoregional control. 2015 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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