Compromised bone strength in patients with alcoholic liver cirrhosis
| Autor: | Danijela Đonić, Jelena Jadžić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Alcoholic liver disease
medicine.medical_specialty Cirrhosis Computer Networks and Communications fracture risk Osteoporosis 030209 endocrinology & metabolism Gastroenterology Bone remodeling 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine medicine Bone mineral business.industry Incidence (epidemiology) medicine.disease bone fragility osteoporosis 3. Good health Osteopenia Hardware and Architecture Medicine alcoholic liver cirrhosis 030211 gastroenterology & hepatology business bone mineral density Software |
| Zdroj: | Medicinski podmladak (2020) 71(3):27-34 Medicinski Podmladak, Vol 71, Iss 3, Pp 27-34 (2020) |
| ISSN: | 0369-1527 |
| Popis: | Osteoporosis and/or osteopenia are frequently observed complications in alcoholic liver disease patients, especially in its irreversible stage (alcoholic liver cirrhosis - ALC). Current literature review regarding osteoporosis incidence increased fracture risk, bone mineral density changes, micro-structural alteration and pathogenetic mechanisms leading to ALC - induced decrease in bone quality is presented. It has been reported that osteoporosis is influenceing significant number of ALC patients, with particular accent on lumbar spine, as most commonly affected skeletal site. Several risk factors and ethio-pathogenic mechanisms have been associated with the loss of bone mineral density, in patients with ALC and other cirrhosis. Certain authors claim that dominant mechanism in ALC-induced bone loss is decrease in bone formation and osteoblastic function, while other results suggest increased bone remodeling as underlying cause of increased bone fragility in ALC patients. Increased bone fragility and susceptibility to osteoporotic fractures significantly affect life expectancy and quality of life in patients with ALC. Thus, osteological screening and individual fracture risk assessment are highly recommended for all patients with alcoholic liver cirrhosis. |
| Databáze: | OpenAIRE |
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