Performance of Screening Breast MRI After Negative Full-Field Digital Mammography Versus After Negative Digital Breast Tomosynthesis in Women at Higher Than Average Risk for Breast Cancer
| Autor: | Pragya A. Dang, Elkan F. Halpern, Constance D. Lehman, Bethany L. Niell, Ashley A. Roark |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty genetic structures Breast Neoplasms Risk Assessment 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Medicine Mammography Breast MRI Humans Radiology Nuclear Medicine and imaging skin and connective tissue diseases False Negative Reactions Early Detection of Cancer Aged Retrospective Studies Aged 80 and over Average risk medicine.diagnostic_test business.industry Cancer General Medicine Digital Breast Tomosynthesis Middle Aged medicine.disease Full field digital mammography Magnetic Resonance Imaging Tomosynthesis 030220 oncology & carcinogenesis Female Radiology business |
| Zdroj: | AJR. American journal of roentgenology. 212(2) |
| ISSN: | 1546-3141 |
| Popis: | The objective of our study was to compare the supplemental cancer yield and performance of breast MRI in women at higher-than-average risk for breast cancer after negative 2D full-field digital mammography (FFDM) or negative digital breast tomosynthesis (DBT).Retrospective review identified 4418 screening breast MRI examinations: 2291 were performed from January 2010 through January 2012 of patients with a negative FFDM examination in the 12 months before MRI (FFDM group), and 2127 were performed from January 2013 through January 2015 of patients with a negative DBT examination in the 12 months before MRI (DBT group). Screening indications included genetic predisposition, personal history of breast cancer or high-risk lesion, prior chest irradiation, family history, or other risk factors conferring a lifetime risk of greater than 20%. Supplemental cancer detection rate (CDR), abnormal interpretation rate (AIR), and positive predictive values (PPVs) were estimated with 95% exact CIs. Logistic regression analysis, adjusting for differences in patient demographics, was used to compare metrics.There was no significant difference in the CDR of MRI in the FFDM group versus the DBT group (11 vs 16 cancers per 1000 examinations, respectively; odds ratio, 1.4; 95% CI, 0.4-1.2; p = 0.23). The AIR, PPV1, PPV2, and PPV3 were 7.4%, 15%, 23%, and 28% for the FFDM group and 7.3%, 22%, 33%, and 35% for the DBT group, with no statistical differences. Of the cancers detected in both groups, the majority were invasive, less than 1 cm, and node-negative.In women at higher-than-average risk of breast cancer screened with DBT, the supplemental CDR of MRI is similar to that of MRI after FFDM screening, with most cancers being invasive, subcentimeter, and node-negative. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|