Exosomal let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors
| Autor: | Bei Cheng, Yan Lu, Yu Ma, Ling Hou, Lanyun Zhou, Bingjian Lu, Mengyue Zheng, Weiguo Lu, Fenfen Wang, Wei Wang, Pengyuan Liu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Uterine Cervical Neoplasms Biology Cervical intraepithelial neoplasia Sensitivity and Specificity lcsh:RC254-282 Exosome 03 medical and health sciences 0302 clinical medicine Internal medicine Diagnosis microRNA Biomarkers Tumor medicine Humans Diagnostic biomarker Liquid biopsy Letter to the Editor Early Detection of Cancer Aged Retrospective Studies miRNA Cervical cancer Cancer prevention Sequence Analysis RNA Non invasive Early detection Middle Aged Uterine Cervical Dysplasia lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease MicroRNAs 030104 developmental biology Area Under Curve 030220 oncology & carcinogenesis Next-generation sequencing Molecular Medicine Female |
| Zdroj: | Molecular Cancer, Vol 18, Iss 1, Pp 1-8 (2019) Molecular Cancer |
| ISSN: | 1476-4598 |
| DOI: | 10.1186/s12943-019-0999-x |
| Popis: | Cervical cancer screening through detection and treatment of high-grade cervical intraepithelial neoplasia (CIN) is most successful in cancer prevention. However, the accuracy of the current cervical cancer screening tests is still low. The aim of this study was to develop a more accurate method based on circulating exosomal miRNAs. The miRNA sequencing was performed to identify candidate exosomal miRNAs as diagnostic biomarkers in 121 plasma samples from healthy volunteers, cervical carcinoma patients, and CIN patients. A panel with eight differentially expressed exosomal miRNAs was identified to distinguish patients in the CIN II+ group (including advanced CIN II patients) from those in the CIN I− group (including CIN I patients and healthy volunteers). Let-7d-3p and miR-30d-5p showed significant difference between cervical tumors and adjacent normal tissues (P |
| Databáze: | OpenAIRE |
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