Impact of pregnancy on the function of transplanted kidneys
| Autor: | N Quintero, M. Espinoza, E Reynolds, Fernando González, Oscar Espinoza, S Herrera, T Galdo, E Roessler |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Urinary system Urology Renal function Blood Pressure Preeclampsia chemistry.chemical_compound Pregnancy medicine Humans Kidney transplantation Retrospective Studies Transplantation Creatinine business.industry Pregnancy Outcome medicine.disease Delivery Obstetric Kidney Transplantation Surgery Pregnancy Complications Blood pressure chemistry Drug Therapy Combination Female business Immunosuppressive Agents |
| Zdroj: | Transplantation proceedings. 37(3) |
| ISSN: | 0041-1345 |
| Popis: | Introduction. This study reviewed the course of pregnancies in terms of impact on renal function and delivery-related data among women who received kidney transplants in our unit. Methods. We reviewed the medical records of women transplanted between 1982 and 2002 who became pregnant. We recorded the data of medical, obstetrical, and transplant-related complications, plasma creatinine levels, and blood pressures at baseline, delivery, and 12 months after delivery. Results. Thirty women had 37 pregnancies. Immunosuppressive protocols included cyclosporine, ketoconazole, azathioprine, and prednisone in 22 patients or azathioprine and prednisone in 15. Renal function decreased significantly: mean creatinine levels at baseline, delivery, and after 1 year were: 1.19 ± 0.38 mg/dL; 1.44 ± 0.70 mg/dL; and 1.38 ± 0.53 mg/dL, respectively (P = .023 and P = .004 vs baseline respectively). Systolic and diastolic blood pressures at delivery were higher than at baseline (134 ± 19 and 86 ± 14 mm Hg vs 126 ± 21 and 79 ± 13 mm Hg (P = .029 and P = .053, respectively). These values normalized 1 year later (128 ± 21 and 80 ± 16). Decreased use of antihypertensive drugs were the cause of poor blood pressure control (1.8 ± 1.3 vs 0.9 ± 0.7, P |
| Databáze: | OpenAIRE |
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