Self‐sampling as the Principal Modality for Population Based Cervical Screening: Five‐year Follow‐up of the PaVDaG Study
| Autor: | Marc Arbyn, Grazyna A. Stanczuk, Timothy M. Palmer, William Forson, Gwendoline Baxter, Kate Cuschieri, A. Wilson, James R. Lawrence, Heather Currie |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
HPV Cancer Research medicine.medical_specialty Uterine Cervical Neoplasms Population based Cervical intraepithelial neoplasia RISK HUMAN-PAPILLOMAVIRUS medicine Humans Mass Screening ASSAYS cervical screening Longitudinal Studies human papillomavirus Early Detection of Cancer Vaginal Smears Cervical screening business.industry Obstetrics Papillomavirus Infections Five year follow up WOMEN self-sampling Future assessment Middle Aged medicine.disease PREVENTION Predictive value female genital diseases and pregnancy complications Self Care Oncology Cohort Female business Follow-Up Studies Self sampling |
| Zdroj: | International Journal of Cancer INTERNATIONAL JOURNAL OF CANCER |
| ISSN: | 0020-7136 1097-0215 |
| DOI: | 10.1002/ijc.33888 |
| Popis: | Self-sampling provides a powerful means to engage women in cervical screening. In the original Papillomavirus Dumfries and Galloway study (PaVDaG), we demonstrated cross-sectional similarity of high-risk human papillomavirus (Hr-HPV) testing on self-taken vaginal vs clinician-taken samples for the detection of cervical intraepithelial neoplasia 2 or worse (CIN2+). Few data exist on the longitudinal performance of self-sampling; we present longitudinal outcomes of PaVDaG. Routinely screened women provided a self-taken and a clinician-collected sample. Ninety-one percent of 5136 women from the original cohort completed a further screening round. Sensitivity, specificity, positive predictive value and complement of the negative predictive value of the Hr-HPV test on self-samples for detection of CIN2+ and CIN3+ up-to 5 years after testing were determined. Additionally, clinical accuracy of Hr-HPV testing on vaginal and clinician-collected samples was assessed. A total of 183 CIN2+ and 102 CIN3+ lesions were diagnosed during follow-up. Risk of CIN2+ and CIN3+ following an Hr-HPV negative self-sample was 0.6% and 0.2%, respectively, for up to 5 years after testing. The relative sensitivity for CIN3+ and specificity for |
| Databáze: | OpenAIRE |
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