Sulphurous thermal water increases the release of the anti-inflammatory cytokine IL-10 and modulates antioxidant enzyme activity
| Autor: | Laura Buizza, Stefano Calza, Silvano Sozzani, Daniela Uberti, Mariagrazia Marziano, Valentina Salvi, Daniela Bosisio, Chiara Prandelli, Valeria Zacchi, Maurizio Memo, Andrea Delbarba, Carmen Parola |
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| Předmět: |
Male
Saliva Time Factors Antioxidant medicine.medical_treatment Respiratory Tract Diseases Anti-Inflammatory Agents NADPH Oxidase Antioxidants Hot Springs Leukocytes enzymology/immunology/therapy Immunology and Allergy Cells Cultured Cultured biology Middle Aged Catalase Enzymes Interleukin-10 Interleukin 10 Cytokine Adult Aged Anti-Inflammatory Agents pharmacology Antioxidants pharmacology Balneology Catalase metabolism Cells Cultured Enzymes metabolism Female Glutathione Peroxidase metabolism Hot Springs Humans Inflammation Mediators metabolism Inflammation enzymology/immunology/therapy Interleukin-10 metabolism Italy Leukocytes Mononuclear drug effects/enzymology/immunology Male Middle Aged Mineral Waters NADPH Oxidase metabolism Reactive Oxygen Species metabolism Respiratory Tract Diseases enzymology/immunology/therapy Saliva enzymology/immunology Sulfides pharmacology Superoxide Dismutase metabolism Time Factors Italy Female Inflammation Mediators Adult medicine.medical_specialty drug effects/enzymology/immunology medicine.drug_class Cells Sodium Immunology chemistry.chemical_element Sulfides Anti-inflammatory Aged pharmacology Balneology metabolism Glutathione Peroxidase Humans Inflammation Mineral Waters Reactive Oxygen Species enzymology/immunology Superoxide Dismutase Internal medicine medicine Pharmacology NADPH Oxidases Enzyme assay Endocrinology chemistry Leukocytes Mononuclear biology.protein |
| Zdroj: | Scopus-Elsevier ResearcherID Europe PubMed Central |
| Popis: | The beneficial effects of hot springs have been known for centuries and treatments with sulphurous thermal waters are recommended in a number of chronic pathologies as well as acute recurrent infections. However, the positive effects of the therapy are often evaluated in terms of subjective sense of wellbeing and symptomatic clinical improvements. Here, the effects of an S-based compound (NaSH) and of a specific sulphurous thermal water characterized by additional ions such as sodium chloride, bromine and iodine (STW) were investigated in terms of cytokine release and anti-oxidant enzyme activity in primary human monocytes and in saliva from 50 airway disease patients subjected to thermal treatments. In vitro, NaSH efficiently blocked the induction of pro-inflammatory cytokines and counterbalanced the formation of ROS. Despite STW not recapitulating these results, possibly due to the low concentration of S-based compounds reached at the minimum non-toxic dilution, we found that it enhanced the release of IL-10, a potent anti-inflammatory cytokine. Notably, higher levels of IL-10 were also observed in patients' saliva following STW treatment and this increase correlated positively with salivary catalase activity (r2 = 0.19, *p less than 0.01). To our knowledge, these results represent the first evidence suggesting that S-based compounds and STW may prove useful in facing chronic inflammatory and age-related illness due to combined anti-inflammatory and anti-oxidant properties. |
| Databáze: | OpenAIRE |
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