Pharmacokinetics of liposomal amphotericin B during extracorporeal albumin dialysis
| Autor: | Rosa Bellmann-Weiler, Romuald Bellmann, Michael Joannidis, Jordan Kountchev, Helene Vogelsinger, Christian J. Wiedermann |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Antifungal Agents medicine.medical_treatment Biomedical Engineering Medicine (miscellaneous) Graft vs Host Disease Bioengineering Pharmacology Extracorporeal Biomaterials Pharmacokinetics Renal Dialysis Albumins Amphotericin B parasitic diseases Hemofiltration medicine Humans Liposome urogenital system business.industry technology industry and agriculture Albumin General Medicine bacterial infections and mycoses medicine.disease Antimicrobial Graft-versus-host disease Immunology business Dialysis (biochemistry) Liver Failure |
| Zdroj: | Artificial organs. 30(2) |
| ISSN: | 0160-564X |
| Popis: | Extracorporeal blood purification techniques such as hemofiltration or albumin dialysis can exert a significant, but not easily predictable influence on plasma pharmacokinetics of antimicrobial agents. The effect of albumin dialysis on the pharmacokinetics of liposomal amphotericin B (AMB) and other lipid-formulated drugs has not been investigated so far. Therefore, plasma concentrations of liberated and liposomal AMB were measured in a patient, who obtained liposomal AMB for suspected invasive mycosis and required albumin dialysis because of cholestatic liver failure caused by graft versus host disease after bone marrow transplantation. Liberated and liposomal AMB were separated by solid phase extraction and measured by high performance liquid chromatography. No excessive AMB elimination took place during albumin dialysis. Plasma levels of liposomal AMB exceeded those of liberated AMB. Pharmacokinetic data were comparable to those obtained previously in patients on hemofiltration and in critically ill patients without extracorporeal blood purification. |
| Databáze: | OpenAIRE |
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