Comparative effects of genistein and bisphenol A on non-alcoholic fatty liver disease in laying hens
| Autor: | Zhihui Tang, Xiaona Gao, Nobuhle Hyacinth Mhlambi, Wentao Fan, Liping Yan, Shuhui Liu, Zhangshan Gao, Chenchen Ding, Yufan Miao, Mengcong Li, Suquan Song |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
medicine.medical_specialty Health Toxicology and Mutagenesis Genistein Inflammation Toxicology chemistry.chemical_compound Insulin resistance Phenols Non-alcoholic Fatty Liver Disease Internal medicine medicine Animals Benzhydryl Compounds Receptor business.industry Fatty liver nutritional and metabolic diseases General Medicine medicine.disease Pollution digestive system diseases Endocrinology Liver chemistry Selective estrogen receptor modulator Female Steatosis Metabolic syndrome medicine.symptom business Chickens |
| Zdroj: | Environmental Pollution. 288:117795 |
| ISSN: | 0269-7491 |
| DOI: | 10.1016/j.envpol.2021.117795 |
| Popis: | Bisphenol A (BPA) and genistein (GEN) are selective estrogen receptor modulators, which are involved in the occurrence and development of metabolic syndrome. However, their roles in non-alcoholic fatty liver disease (NAFLD) of laying hens have not been reported. Here, we investigated the effects of different concentrations of GEN and BPA on the NAFLD of laying hens. Results showed that GEN ameliorated the high-energy and low-protein diet (HELP)-induced NAFLD by improving pathological damage, hepatic steatosis, and insulin resistance and blocking the expression of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-related factors. By contrast, high dose of BPA could aggravate these changes with serious symptom of NAFLD and suppress the level of ERα in the liver considerably, while GEN could reverse this phenomenon in a dose-dependent manner. In general, our research shows that the protective effect of GEN on NAFLD aims to improve the metabolic disorders and inflammation closely connected to ERα, while BPA can inhibit the expression of ERα and exacerbate the symptom of NAFLD. In conclusion, we elucidate the opposing effects of GEN and BPA in NAFLD of laying hens, thus providing a potential mechanism related to ERα and inflammation. |
| Databáze: | OpenAIRE |
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