Short-term effect of non-surgical periodontal treatment on local and systemic cytokine levels: Role of hyperglycemia
| Autor: | Giovane Hisse Gomes, Christopher W. Cutler, Giuseppe Alexandre Romito, Mariana de Sousa Rabelo, Adriana Moura Foz, Amanda Finger Stadler, Cristiano Susin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Blood Glucose Male medicine.medical_specialty Saliva Time Factors medicine.medical_treatment Immunology Administration Oral Inflammation Granulocyte Biochemistry Generalized periodontitis Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy Humans Interferon gamma Periodontitis Molecular Biology Aged business.industry Hematology Gingival Crevicular Fluid Middle Aged medicine.disease 030104 developmental biology Cytokine medicine.anatomical_structure Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Hyperglycemia Cytokines Tumor necrosis factor alpha Female medicine.symptom Inflammation Mediators business Biomarkers medicine.drug |
| Zdroj: | Cytokine |
| ISSN: | 1096-0023 |
| Popis: | BACKGROUND The effect of non-surgical periodontal treatment on oral and systemic inflammatory mediators in subjects with periodontitis and hyperglycemia remains largely unknown. Therefore, the aim of this clinical study was to compare the short-term effect of non-surgical periodontal treatment on serum, saliva and GCF inflammatory markers levels in GP subjects with or without hyperglycemia. METHODS Sixty subjects divided into four groups of equal size were selected to participate: type 2 diabetics with generalized periodontitis (T2DM + GP), pre-diabetics with GP (PD + GP), normoglycemic subjects with GP (NG + GP), and healthy controls. GCF, serum, and saliva samples were obtained at baseline and 30 days after scaling and root planning (SRP) and the levels of interleukin-1β (IL-1 β), IL-8, IL-6, IL-2, IL-5, IL-4, IL-10, Interferon gamma (IFN-γ), Granulocyte macrophage colony-stimulating factor (GM-CSF) and Tumor necrosis factor-alpha (TNF-α) were determined by ultrasensitive multiplex assay. Clinical periodontal measurements were recorded. RESULTS SRP yielded significant improvement of all periodontal parameters for all GP groups (p |
| Databáze: | OpenAIRE |
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