COVID-19 mortality is associated with low vitamin D levels in patients with risk factors and/or advanced age
| Autor: | Irén Hegedüs, Béla Büki, Sándor Jenei, Márta Knausz, Tamas F. Molnar, Imre Dinnyés, Ákos Putics, Tímea Jenei, Zsuzsanna Szalai, László T. Tamás |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Short Communication vitamin D deficiency Elderly Risk Factors Diabetes mellitus Internal medicine medicine Vitamin D and neurology Humans Prospective Studies Risk factor Vitamin D Prospective cohort study Retrospective Studies COPD Nutrition and Dietetics business.industry SARS-CoV-2 Cancer COVID-19 Retrospective cohort study Middle Aged medicine.disease business |
| Zdroj: | Clinical Nutrition Espen |
| ISSN: | 2405-4577 |
| Popis: | Summary BACKGROUND & AIMS Although conclusive evodence is yet lacking, it has been suggested that vitamin D deficiency (VD) may be associated with a more severe course of SARS-CoV-2 Infection (COVID-19). In this retrospective study we assessed the association of VD deficiency with mortality in a group of COVID-19 patients treated in a tertiary referral center. METHODS Data of 257 Covid-19 patients hospitalized between 30th September 2020 and 2nd March 2021 have been collected retrospectively. The following parameters were collected: age, gender, serum level of 25-OH-Vitamin D3, outcome (survival/death) comorbidities (cancer, diabetes mellitus and chronic obstructive pulmonary disease). Serum VD measurement was done within 3 days of admission. RESULTS VD levels were significantly lower in patients who did not survive, however, in this patients’ group the average age was significantly higher than among those, who survived. After age-matching, in a subgroup of patients with risk factors and/or 60 years of age or older who survived had significantly higher VD level in their serum than those who deceased. Serum C-reactive protein, lactate-dehydrogenase and creatinin-kinase were significantly higher in the group in which the patients died, however these laboratory parameters did not correlate with the VD levels. CONCLUSION We found that in COVID-19 infection, when old age as risk factor (60 years of age or older) was pooled with risk factors (cancer, diabetes and/or COPD), the VD levels were significantly lower in the patient group, in which the patients did not survive. We suggest further, prospective studies in similar subgroups to explore a possible causal relationship. |
| Databáze: | OpenAIRE |
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