Processing, physico-chemical characterisation and in vitro evaluation of silicon containing β-tricalcium phosphate ceramics
| Autor: | Roxana Chotard-Ghodsnia, Chantal Damia, U. Deisinger, Rainer Detsch, Nathalie Douard, Eric Champion |
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| Přispěvatelé: | Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), BioCer Entwicklung GmbH, BioCer, Axe 1 : procédés céramiques, Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Friedrich Baur Research Institute for Biomaterials |
| Rok vydání: | 2011 |
| Předmět: |
Materials science
Silicon chemistry.chemical_element Mineralogy Sintering Bioengineering 02 engineering and technology complex mixtures 01 natural sciences Biomaterials Tricalcium phosphate Silicon X-ray photoelectron spectroscopy 0103 physical sciences Ceramic 010302 applied physics Rietveld refinement technology industry and agriculture In vitro evaluation equipment and supplies 021001 nanoscience & nanotechnology Grain size Amorphous solid Powder synthesis chemistry Chemical engineering Mechanics of Materials Transmission electron microscopy visual_art visual_art.visual_art_medium 0210 nano-technology |
| Zdroj: | Materials Science and Engineering: C Materials Science and Engineering: C, Elsevier, 2011, 31, pp.531-539. ⟨10.1016/j.msec.2010.11.008⟩ |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2010.11.008 |
| Popis: | article i nfo For bone grafting applications, the elaboration of silicon containing beta-tricalcium phosphate (β-TCP) was studied. The synthesis was performed using a wet precipitation method according to the hypothetical theoretical formula Ca3 −x(PO4)2 −2x(SiO4)x. Two silicon loaded materials (0.46 wt.% and 0.95 wt.%) were investigated and compared to a pure β-TCP. The maturation time of the synthesis required in order to obtain β-TCP decreased with the amount of silicon. Only restrictive synthesis conditions allow preparing silicon containing β-TCP with controlled composition. To obtain dense ceramics, the sintering behaviour of the powders was evaluated. The addition of silicon slowed the densification process and decreased the grain size of the dense ceramics. Rietveld refinement may indicate a partial incorporation of silicon in the β-TCP lattice. X-ray photoelectron spectroscopy and transmission electron microscopy analyses revealed that the remaining silicon formed amorphous clusters of silicon rich phase. The in vitro biological behaviour was investigated with MC3T3-E1 osteoblast-like cells. After the addition of silicon, the ceramics remained cytocompatible, highlighting the high potential of silicon containing β-TCP as optimised bone graft material. © 2010 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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