RGD Cyclopeptide Equipped with a Lysine-Engaging Salicylaldehyde Showing Enhanced Integrin Affinity and Cell Detachment Potency

Autor:	Giovanni Sacco, Daniela Arosio, Mayra Paolillo, Andreas Gloger, Jörg Scheuermann, Luca Pignataro, Laura Belvisi, Alberto Dal Corso, Cesare Gennari
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	peptidomimetics Organic Chemistry aldehydes cell adhesion covalent inhibitors integrins Settore CHIM/06 - Chimica Organica General Chemistry Catalysis
Zdroj:	Chemistry-A European Journal, 29 (19)
ISSN:	0947-6539 1521-3765
Popis:	Salicylaldehyde (SA) derivatives are emerging as useful fragments to obtain reversible-covalent inhibitors interacting with the lysine residues of the target protein. Here the SA installation at the C terminus of an integrin-binding cyclopeptide, leading to enhanced ligand affinity for the receptor as well as stronger biological activity in cultured glioblastoma cells is reported. Chemistry - A European Journal, 29 (19) ISSN:0947-6539 ISSN:1521-3765
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb3e17944199a3240f1e4a8b4bc561d https://hdl.handle.net/20.500.11850/604148 Zobrazit plný text záznamu Plný text