Adverse respiratory outcomes associated with occupational exposures at a soy processing plant
| Autor: | Kristin J. Cummings, Brett J. Green, Toni A. Bledsoe, Donald H. Beezhold, Kathleen Kreiss, Greg Kullman, Denise M. Gaughan, Jean M. Cox-Ganser, Francoise M. Blachere |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Spirometry Allergy medicine.medical_specialty Air Pollutants Occupational Logistic regression Skin Diseases Occupational medicine Young Adult Risk Factors Occupational Exposure Internal medicine Wheeze Prevalence medicine Humans Sinusitis Aged Asthma medicine.diagnostic_test business.industry Respiratory disease Soy Foods Immunoglobulin E Middle Aged medicine.disease Health Surveys respiratory tract diseases Occupational Diseases Immunoglobulin G Immunology Female medicine.symptom business |
| Zdroj: | European Respiratory Journal. 36:1007-1015 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.00151109 |
| Popis: | This study aimed to characterise the relationship between adverse health outcomes and occupational risk factors among workers at a soy processing plant. A questionnaire, spirometry, methacholine challenge, immune testing and air sampling for dust and soy were offered. Prevalence ratios (PRs) of respiratory problems from comparisons with the US adult population were calculated. Soy-specific immunoglobulin (Ig)G and IgE among participants and healthcare worker controls were compared. Associations between health outcomes and potential explanatory variables were examined using logistic regression. 147 (52%) out of 281 employees, including 66 (70%) out of 94 production workers, participated. PRs were significantly elevated for wheeze, sinusitis, ever-asthma and current asthma. Participants had significantly higher mean concentrations of soy-specific IgG (97.9 mg·L −1 versus 1.5 mg·L −1 ) and prevalence of soy-specific IgE (21% versus 4%) than controls. Participants with soy-specific IgE had three-fold greater odds of current asthma or asthma-like symptoms, and six-fold greater odds of work-related asthma-like symptoms; the latter additionally was associated with production work and higher peak dust exposures. Airways obstruction was associated with higher peak dust. Work-related sinusitis, nasal allergies and rash were associated with reported workplace mould exposure. Asthma and symptoms of asthma, but not other respiratory problems, were associated with immune reactivity to soy. |
| Databáze: | OpenAIRE |
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