Interleukin-8 derived from local tissue-resident stromal cells promotes tumor cell invasion
| Autor: | Srinivasalu Krishnappa, Eswaran Devarajan, Constantin Jotzu, Gabriel Welte, Yao-Hua Song, Eckhard Alt |
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| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
Stromal cell Adipose tissue Breast Neoplasms Biology Paracrine signalling Cell Movement Cell Line Tumor Tumor Microenvironment Lymph node stromal cell Humans Neoplasm Invasiveness Interleukin 8 Molecular Biology Cells Cultured Cell Proliferation Oligonucleotide Array Sequence Analysis Interleukin-8 Nestin Coculture Techniques Up-Regulation Adipose Tissue Immunology Cancer cell Cancer research Female Stromal Cells Stem cell |
| Zdroj: | Molecular Carcinogenesis. 51:861-868 |
| ISSN: | 0899-1987 |
| Popis: | The aim of this study is to evaluate the role of adipose tissue resident stromal cells on tumor cell invasion. Our data show that a subpopulation of adipose tissue derived stromal cells expressing Nestin, NG2, α-smooth muscle actin and PDGFR-α migrate toward the cancer cells. Microarray analysis revealed the upregulation of IL-8 in the migrated cells. We demonstrated that stromal cell derived IL-8 promote the invasion and the anchorage-independent growth of cancer cells. We conclude that human breast cancer cells attract a subpopulation of stromal cells that secrete IL-8 to promote tumor cell invasion in a paracrine fashion. © 2011 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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