Response to letter regarding 'myostatin regulates energy homeostasis in the heart and prevents heart failure'
| Autor: | Thomas Braun, Nadine Biesemann |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cardiac function curve
Heart Failure medicine.medical_specialty Ejection fraction biology Physiology Myocardium Estrogen receptor Myostatin medicine.disease Energy homeostasis Contractility Endocrinology Heart failure Internal medicine medicine biology.protein Cardiomyopathy Hypertrophic Familial Animals skin and connective tissue diseases Cardiology and Cardiovascular Medicine Energy Metabolism Tamoxifen medicine.drug |
| Zdroj: | Circulation research. 116(7) |
| ISSN: | 1524-4571 |
| Popis: | In the article1 referred to in Drs McLean and Oudit’s letter,2 we ana lyzed the effects of inactivation of myostatin in adult cardiomyocytes. Drs McLean and Oudit correctly point out that treatment of mice with tamoxifen to induce activation of cre recombinase estrogen receptor fusion proteins causes transient systolic dysfunctions.3 They expressed concern that the relatively high dosage of tamoxifen administered in our experiments (100 mg/kg daily for up to 5 days) contributed to decreased survival, transient impairment of contractility, and cardiomyocyte hypertrophy in adult cardiomyocyte-specific myostatin mutants.1 In our experiments, we always directly compared tamoxifen-treated αMyHC-MCM/Mstnfl/fl with tamoxifen-treated αMyHC-MCM mice, which in our view is the best possible control. In tamoxifen-treated αMyHC-MCM mice, we only observed a mild depression of cardiac function without any effect on lethality while tamoxifen-treated αMyHC-MCM/Mstnfl/fl presented with a >50% reduced ejection fraction, nearly 30% lethality and a massive enlargement of the right atria, which was never seen in any tamoxifen-treated control mice described in the literature or analyzed in our laboratory. The majority of tamoxifen related side-effects reported a return to baseline levels 10 days after the first injection in most published … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|