Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice

Autor: Layasadat Khorsandi, Fereshteh Nejad-Dehbashi, Samaneh Karimi
Rok vydání: 2019
Předmět:
Zdroj: JBRA Assisted Reproduction
ISSN: 1518-0557
DOI: 10.5935/1518-0557.20190031
Popis: Objective: In this study, we investigated the preventing effects of Curcumin (Cur) against titanium dioxide nanoparticle (NTiO2)-induced mouse testicular damage. Methods: We assessed NTiO2-intoxicated mice received 50mg/kg of NTiO2 for 35 days. The Cur + NTiO2 group was pretreated with Cur (200 mg/kg) for 7 days prior to administering NTiO2. Sperm parameters, testosterone concentration, histological criteria, morphometric parameters and Johnsen's scoring. Results: NTiO2 significantly reduced testicular weight, testosterone concentration, morphometric parameters, Johnsen's scoring and sperm quality (p
Databáze: OpenAIRE