Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice
Autor: | Layasadat Khorsandi, Fereshteh Nejad-Dehbashi, Samaneh Karimi |
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Rok vydání: | 2019 |
Předmět: |
Male
0301 basic medicine endocrine system sperm quality mice Curcumin Motility Protective Agents Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Testis Animals Sperm quality Testosterone Titanium nanoparticle Organ Size Spermatozoa Sperm spermatogenesis 030104 developmental biology chemistry Vacuolization 030220 oncology & carcinogenesis testosterone Sperm Motility Nanoparticles Testicular toxicity Original Article Spermatogenesis |
Zdroj: | JBRA Assisted Reproduction |
ISSN: | 1518-0557 |
DOI: | 10.5935/1518-0557.20190031 |
Popis: | Objective: In this study, we investigated the preventing effects of Curcumin (Cur) against titanium dioxide nanoparticle (NTiO2)-induced mouse testicular damage. Methods: We assessed NTiO2-intoxicated mice received 50mg/kg of NTiO2 for 35 days. The Cur + NTiO2 group was pretreated with Cur (200 mg/kg) for 7 days prior to administering NTiO2. Sperm parameters, testosterone concentration, histological criteria, morphometric parameters and Johnsen's scoring. Results: NTiO2 significantly reduced testicular weight, testosterone concentration, morphometric parameters, Johnsen's scoring and sperm quality (p |
Databáze: | OpenAIRE |
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